Differential gene expression and developmental pathologies associated with persistent organic pollutants in sentinel fish in Troutman Lake, Sivuqaq, Alaska

R Jordan-Ward, FA von Hippel, CA Wilson… - Environmental …, 2024 - Elsevier
Persistent organic pollutants (POPs) are lipophilic compounds that bioaccumulate in
animals and biomagnify within food webs. Many POPs are endocrine disrupting compounds …

Development of the integrated fish endocrine disruptor test—Part B: Implementation of thyroid‐related endpoints

L Gölz, P Pannetier, T Fagundes… - Integrated …, 2024 - Wiley Online Library
Given the vital role of thyroid hormones (THs) in vertebrate development, it is essential to
identify chemicals that interfere with the TH system. Whereas, among nonmammalian …

Single-cell Iso-Sequencing enables rapid genome annotation for scRNAseq analysis

HM Healey, S Bassham, WA Cresko - Genetics, 2022 - academic.oup.com
Single-cell RNA sequencing is a powerful technique that continues to expand across
various biological applications. However, incomplete 3′-UTR annotations can impede …

Endocrine disruption and differential gene expression in sentinel fish on St. Lawrence Island, Alaska: health implications for indigenous residents

FA von Hippel, PK Miller, DO Carpenter, D Dillon… - Environmental …, 2018 - Elsevier
People living a subsistence lifestyle in the Arctic are highly exposed to persistent organic
pollutants, including polychlorinated biphenyls (PCBs). Formerly Used Defense (FUD) sites …

Transcriptomic and developmental effects of persistent organic pollutants in sentinel fishes collected near an arctic formerly used defense site

R Jordan-Ward, FA von Hippel, MES Santos… - Environmental …, 2024 - Elsevier
Alaska contains over 600 formerly used defense (FUD) sites, many of which serve as point
sources of pollution. These sites are often co-located with rural communities that depend …

Research advances in identification procedures of endocrine disrupting chemicals

X Guo, B Liu, H Liu, X Du, X Chen, W Wang… - … Science and Pollution …, 2023 - Springer
Endocrine disrupting chemicals (EDCs) are increasingly concerned substance endangering
human health and environment. However, there is no unified standard for identifying …

Sodium perchlorate induces non-alcoholic fatty liver disease in developing stickleback

MR Minicozzi, FA von Hippel, CG Furin, CL Buck - Environmental Pollution, 2019 - Elsevier
Perchlorate is a pervasive, water-soluble contaminant that competitively inhibits the
sodium/iodide symporter, reducing the available iodide for thyroid hormone synthesis …

Experimental copper exposure, but not heat stress, leads to elevated intraovarian thyroid hormone levels in three-spined sticklebacks (Gasterosteus aculeatus)

R Suvi, M Giovanna, A Katja - Ecotoxicology, 2020 - Springer
Climate change and pollution are some of the greatest anthropogenic threats to wild
animals. Transgenerational plasticity—when parental exposure to environmental stress …

Perchlorate exposure does not induce obesity or non-alcoholic fatty liver disease in zebrafish

MR Minicozzi, EG Axlid, FA von Hippel, J Espinoza… - Plos one, 2021 - journals.plos.org
Perchlorate is a water-soluble contaminant found throughout the United States and many
other countries. Perchlorate competitively inhibits iodide uptake at the sodium/iodide …

[HTML][HTML] Effects of sodium perchlorate and exogenous L‐thyroxine on growth, development and leptin signaling pathway of Bufo gargarizans tadpoles during …

R Zheng, R Liu, M Wu, H Wang, L Xie - Ecotoxicology and Environmental …, 2020 - Elsevier
Sodium perchlorate (NaClO 4) and exogenous L‐thyroxine (T4), two kinds of endocrine-
disrupting chemicals (EDCs), mainly affect the circulating thyroid hormones, which regulate …