In response to an ever-increasing demand of new small molecules therapeutics, numerous
chemical and genetic tools have been developed to interrogate compound mechanism of …

Multifaceted interrogation of the proteome deepens the system‐wide understanding of
biological systems; however, mapping the redox changes in the proteome has so far been …

Target deconvolution can help understand how compounds exert therapeutic effects and
can accelerate drug discovery by helping optimise safety and efficacy, revealing …

Method development for mass spectrometry (MS)-based thermal shift proteomic assays
have advanced to probe small molecules with known and unknown protein-ligand …

Antimicrobial resistance is responsible for an alarming number of deaths, estimated at 5
million per year. To combat priority pathogens, like Helicobacter pylori, the development of …

Thermal proteome profiling (TPP) is a powerful tool for drug target deconvolution. Recently,
data‐independent acquisition mass spectrometry (DIA‐MS) approaches have demonstrated …

Comprehensive Summary Protein‐protein interactions (PPIs) play a crucial role in drug
discovery and disease treatment. However, the development of effective drugs targeting …

Knowledge of the targets of therapeutic compounds is vital for understanding their action
mechanisms and side effects, but such valuable data is seldom available. The multiple …

Thermal proteome profiling effectively investigates protein-protein, protein-nucleic acid, or
protein-drug interactions, and the impact of metabolite binding and post-translational …