Long non-coding RNAs (lncRNAs); roles in tumorigenesis and potentials as biomarkers in cancer diagnosis

S Najafi, SH Khatami, M Khorsand, Z Jamali… - Experimental cell …, 2022 - Elsevier
New research has indicated that long non-coding RNAs (lncRNAs) play critical roles in a
broad range of biological processes, including the pathogenesis of many complex human …

[HTML][HTML] Expanding the horizon of EV-RNAs: LncRNAs in EVs as biomarkers for disease pathways

M Spanos, P Gokulnath, E Chatterjee, G Li, D Varrias… - Extracellular vesicle, 2023 - Elsevier
Extracellular vesicles (EVs) are membrane-bound nanoparticles with different types of cargo
released by cells and postulated to mediate functions such as intercellular communications …

Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition

SM Aboukhatwa, AO Ibrahim, H Aoyama… - Bioorganic …, 2022 - Elsevier
Although a plethora of targeted anticancer small molecule drugs became available, the low
response rate and drug resistance imply the continuous need for expanding the anticancer …

Function of the long noncoding RNAs in hepatocellular carcinoma: classification, molecular mechanisms, and significant therapeutic potentials

A Khan, X Zhang - Bioengineering, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is the most common and serious type of primary liver
cancer. HCC patients have a high death rate and poor prognosis due to the lack of clear …

Application value of circulating LncRNA in diagnosis, treatment, and prognosis of breast cancer

M Li, Y Zhao, H Li, X Deng, M Sheng - Functional & Integrative Genomics, 2023 - Springer
Breast cancer is the malignant tumor with the highest incidence in women worldwide. It is
highly heterogeneous, has a high incidence of drug resistance, recurrence, and metastasis …

[HTML][HTML] Role of long non-coding RNAs and TGF-β signaling in the regulation of breast cancer pathogenesis and therapeutic targets

BM Hussen, HJ Hidayat, SR Abdullah, S Mohamadtahr… - Cytokine, 2023 - Elsevier
The cytokine known as transforming growth factor (TGF) is essential for cell development,
differentiation, and apoptosis in BC. TGF-β dysregulation can either promote or inhibit tumor …

The function of LncRNA-ATB in cancer

A Anbiyaiee, M Ramazii, SS Bajestani… - Clinical and …, 2023 - Springer
Cancer as a progressive and complex disease is caused by early chromosomal changes
and stimulated cellular transformation. Previous studies reported that long non-coding RNAs …

[HTML][HTML] ANKRD22 enhances breast cancer cell malignancy by activating the Wnt/β-catenin pathway via modulating NuSAP1 expression

Y Wu, H Liu, Y Gong, B Zhang… - Bosnian Journal of Basic …, 2021 - ncbi.nlm.nih.gov
Breast cancer is one of the most prevalent malignancies in women worldwide. Although
great advancements have been achieved in the diagnosis and treatment of breast cancer …

LncRNA HCP5: a potential biomarker for diagnosing gastric cancer

S Qin, L Yang, S Kong, Y Xu, B Liang, S Ju - Frontiers in Oncology, 2021 - frontiersin.org
Background It has been reported that long non-coding RNAs (lncRNAs) can be regarded as
a biomarker and had particular clinical significance for early screening and gastric cancer …

Combined identification of three lncRNAs in serum as effective diagnostic and prognostic biomarkers for hepatitis B virus‐related hepatocellular carcinoma

P Fu, B Gong, H Li, Q Luo, Z Huang… - … Journal of Cancer, 2022 - Wiley Online Library
Hepatitis B virus‐related hepatocellular carcinoma (HBV‐related HCC) is a common, highly
invasive malignant tumor associated with a high mortality rate. This study aimed to identify …