PEGylation is a versatile drug delivery technique that presents a particularly wide range of
conjugation chemistry and polymer structure. The conjugated protein can be tuned to …

Palifermin (Kepivance™) is the first therapeutic approved by the Food and Drug
Administration for preventing and managing the oral mucositis provoked by myelotoxic and …

Transplantation of islets in type 1 diabetes (T1D) is limited by poor islet engraftment into the
liver, with two to three donor pancreases required per recipient. We aimed to condition the …

Growth factors, including fibroblast growth factor-7 (FGF-7), are a group of proteins that
stimulate various cellular processes and are often used with carriers to prevent the rapid …

Keratinocyte growth factor (KGF) is a potential therapeutic factor in wound healing. However,
its applications have been restricted due to its low stability, short half-life, and limited target …

The coupling of polyethylene glycol (PEG) to proteins (PEGylation) has become a standard
method to prolong blood circulation of imaging probes and other proteins, liposomes, and …

Keratinocyte growth factor (KGF), a member of the fibroblast growth factor (FGF) family, has
been implicated in some biological processes such as cell proliferation, development and …

Heparin and heparan sulfate are important glycosaminoglycans that can regulate the
activities of many vital proteins, especially the fibroblast growth factor (FGF) family. Because …

Human fibroblast growth factor 7 (hFGF7) is a member of the paracrine‐acting FGF family
and mediates various reactions such as wound healing, tissue homeostasis, and liver …

Abstract Background Palifermin (trade name Kepivance®) is an amino-terminally truncated
recombinant human keratinocyte growth factor 1 (KGF-1) with 140 residues that has been …