Necrotizing enterocolitis: It's not all in the gut

AL Meister, KK Doheny… - Experimental biology and …, 2020 - journals.sagepub.com
Necrotizing enterocolitis is the leading cause of death due to gastrointestinal disease in
preterm neonates, affecting 5–12% of neonates born at a very-low birth weight. Necrotizing …

Curcumin and intestinal inflammatory diseases: molecular mechanisms of protection

K Burge, A Gunasekaran, J Eckert… - International journal of …, 2019 - mdpi.com
Intestinal inflammatory diseases, such as Crohn's disease, ulcerative colitis, and necrotizing
enterocolitis, are becoming increasingly prevalent. While knowledge of the pathogenesis of …

Targeting the human microbiome with antibiotics, probiotics, and prebiotics: gastroenterology enters the metagenomics era

GA Preidis, J Versalovic - Gastroenterology, 2009 - Elsevier
Studies of metagenomics and the human microbiome will tremendously expand our
knowledge of the composition of microbial communities in the human body. As our …

Breast milk lipids and fatty acids in regulating neonatal intestinal development and protecting against intestinal injury

D Ramiro-Cortijo, P Singh, Y Liu, E Medina-Morales… - Nutrients, 2020 - mdpi.com
Human breast milk is the optimal source of nutrition for infant growth and development.
Breast milk fats and their downstream derivatives of fatty acids and fatty acid-derived …

The IκB kinase complex: master regulator of NF-κB signaling

LA Solt, MJ May - Immunologic research, 2008 - Springer
Abstract The Nuclear Factor-kappa B (NF-κB) family of transcription factors regulates the
expression of a wide range of genes critical for immune and inflammatory responses, cell …

Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NF-κB signaling in the intestine

Y Liu, NY Fatheree, N Mangalat… - American Journal of …, 2012 - journals.physiology.org
Necrotizing enterocolitis (NEC) is the leading gastrointestinal cause of mortality and
morbidity in the premature infant. Premature infants have a delay in intestinal colonization by …

The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease

T Mukherjee, N Kumar, M Chawla, DJ Philpott… - Science …, 2024 - science.org
Inflammatory bowel disease (IBD) is an idiopathic, chronic condition characterized by
episodes of inflammation in the gastrointestinal tract. The nuclear factor κB (NF-κB) system …

Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism

A Zani, M Cananzi, F Fascetti-Leon, G Lauriti, VV Smith… - Gut, 2014 - gut.bmj.com
Objective Necrotising enterocolitis (NEC) remains one of the primary causes of morbidity
and mortality in neonates and alternative strategies are needed. Stem cells have become a …

[HTML][HTML] Ontogeny, growth and development of the small intestine: Understanding pediatric gastroenterology

LA Drozdowski, T Clandinin… - World journal of …, 2010 - ncbi.nlm.nih.gov
Throughout our lifetime, the intestine changes. Some alterations in its form and function may
be genetically determined, and some are the result of adaptation to diet, temperature, or …

Immunological aspects of necrotizing enterocolitis models: a review

L Blum, D Vincent, M Boettcher, J Knopf - Frontiers in Immunology, 2024 - frontiersin.org
Necrotizing enterocolitis (NEC) is one of the most devasting diseases affecting preterm
neonates. However, despite a lot of research, NEC's pathogenesis remains unclear. It is …