Advances in macrocyclic chelators for positron emission tomography imaging

M Li, S Wang, Q Kong, X Cheng, H Yan, Y Xing, X Lan… - View, 2023 - Wiley Online Library
In recent years, radiometals have been successfully applied to medicine because of their
breadth of decay properties and increased production and availability. Bifunctional chelators …

Aβ-targeting bifunctional chelators (BFCs) for potential therapeutic and PET imaging applications

O Krasnovskaya, A Kononova, A Erofeev… - International Journal of …, 2022 - mdpi.com
Currently, more than 55 million people live with dementia worldwide, and there are nearly
10 million new cases every year. Alzheimer's disease (AD) is the most common …

HNODThia: A Promising Chelator for the Development of 64Cu Radiopharmaceuticals

I Hierlmeier, A Guillou, DF Earley, A Linden… - Inorganic …, 2023 - ACS Publications
Herein, we present the synthesis and coordination chemistry of copper (II) and zinc (II)
complexes of two novel heterocyclic triazacyclononane (tacn)-based chelators (H NODThia …

Coordination Chemistry of Sulfur-Containing Bifunctional Chelators: Toward in Vivo Stabilization of 64Cu PET Imaging Agents for Alzheimer's Disease

Z Yu, G Blade, BS Bouley, IT Dobrucki… - Inorganic …, 2023 - ACS Publications
The broader utilization of 64Cu positron emission tomography (PET) imaging agents has
been hindered by the unproductive demetalation induced by bioreductants. To advance the …

Csp 3‒H Bond Activation Mediated by a Pd (II) Complex under Mild Conditions

H Na, AJ Wessel, ST Kim, MH Baik… - Inorganic Chemistry …, 2024 - pubs.rsc.org
In this work, we disclose a new pentadentate pyridinophane ligand, N-methyl-N'-(2-
methylpyryl)-2, 11-diaza [3.3](2, 6) pyridinophane (PicCH3N4), and its Pd (II) complexes …

Pentadentate and Hexadentate Pyridinophane Ligands Support Reversible Cu (II)/Cu (I) Redox Couples

G Blade, AJ Wessel, K Terpstra, LM Mirica - Inorganics, 2023 - mdpi.com
Two new ligands were synthesized with the goal of copper stabilization, N, N′-(2-
methylpyridine)-2, 11-diaza [3, 3](2, 6) pyridinophane (PicN4) and N-(methyl), N′-(2 …

N,N-Alkylation Clarifies the Role of N- and O-Protonated Intermediates in Cyclen-Based 64Cu Radiopharmaceuticals

AM Brown, JL Butman, R Lengacher… - Inorganic …, 2022 - ACS Publications
Radioisotopes of Cu, such as 64Cu and 67Cu, are alluring targets for imaging (eg, positron
emission tomography, PET) and radiotherapeutic applications. Cyclen-based macrocyclic …

Facile synthesis of stilbene-derivatized Schiff base ligands and their Cu (II) complexes

D Uehara, P Salas - Tetrahedron Letters, 2023 - Elsevier
Herein we present the synthesis and characterization of three Schiff base ligands
derivatized with stilbene groups and their Cu (II) complexes CuL 1-3, prepared in only three …

Csp3‒H Bond Activation Mediated by a Pd (II) Complex under Mild Conditions

L Mirica, H Na, ST Kim, A Wessel, MH Baik - 2023 - chemrxiv.org
In this work, we disclose a new pentadentate pyridinophane ligand, N-methyl-N'-(2-
methylpyryl)-2, 11-diaza [3.3](2, 6) pyridinophane (PicCH3N4), and its Pd (II) complexes …

Análisis y Determinación de las Propiedades Farmacológicas de Una Serie de Complejos de Cobre (Cu) Con Potencial Para ser Agentes de Radiodiagnóstico del …

SRV Núñez - 2024 - search.proquest.com
El diagnóstico definitivo del Alzheimer se realiza mediante estudios post mortem de
cerebros de pacientes, no obstante, en los últimos años ha sido posible aplicar técnicas …