SARS-CoV-2 antiviral therapy
The development of effective antiviral therapy for COVID-19 is critical for those awaiting
vaccination, as well as for those who do not respond robustly to vaccination. This review …
vaccination, as well as for those who do not respond robustly to vaccination. This review …
SARS-CoV-2 RNA-dependent RNA polymerase as a therapeutic target for COVID-19
ABSTRACT Introduction: The current SARS-CoV-2 pandemic urgently demands for both
prevention and treatment strategies. RNA-dependent RNA-polymerase (RdRp), which has …
prevention and treatment strategies. RNA-dependent RNA-polymerase (RdRp), which has …
β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells
Mutagenic ribonucleosides can act as broad-based antiviral agents. They are metabolized
to the active ribonucleoside triphosphate form and concentrate in genomes of RNA viruses …
to the active ribonucleoside triphosphate form and concentrate in genomes of RNA viruses …
Baicalein and baicalin inhibit SARS-CoV-2 RNA-dependent-RNA polymerase
Coronavirus Disease 2019 (COVID-19) is a deadly emerging infectious disease caused by
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Because SARS-CoV-2 …
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Because SARS-CoV-2 …
[HTML][HTML] Effect of tenofovir disoproxil fumarate and emtricitabine on nasopharyngeal SARS-CoV-2 viral load burden amongst outpatients with COVID-19: a pilot …
JJ Parienti, T Prazuck, L Peyro-Saint-Paul… - …, 2021 - thelancet.com
Background Tenofovir and emtricitabine interfere with the SARS CoV-2 ribonucleic acid
(RNA)-dependent RNA polymerase (RdRp). Several cohorts reported that people treated by …
(RNA)-dependent RNA polymerase (RdRp). Several cohorts reported that people treated by …
Recent drug development and medicinal chemistry approaches for the treatment of SARS‐CoV‐2 infection and COVID‐19
Abstract COVID‐19, caused by SARS‐CoV‐2 infection, continues to be a major public
health crisis around the globe. Development of vaccines and the first cluster of antiviral …
health crisis around the globe. Development of vaccines and the first cluster of antiviral …
Nucleoside analogs and nucleoside precursors as drugs in the fight against SARS-CoV-2 and other coronaviruses
Coronaviruses (CoVs) are positive-sense RNA enveloped viruses, members of the family
Coronaviridae, that cause infections in a broad range of mammals including humans …
Coronaviridae, that cause infections in a broad range of mammals including humans …
[HTML][HTML] A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents
TND Do, K Donckers, L Vangeel, AK Chatterjee… - Antiviral research, 2021 - Elsevier
There are, besides remdesivir, no approved antivirals for the treatment of SARS-CoV-2
infections. To aid in the search for antivirals against this virus, we explored the use of human …
infections. To aid in the search for antivirals against this virus, we explored the use of human …
Drug repurposing against SARS-CoV-1, SARS-CoV-2 and MERS-CoV
Since the beginning of the COVID-19 pandemic, large in silico screening studies and
numerous in vitro studies have assessed the antiviral activity of various drugs on SARS-CoV …
numerous in vitro studies have assessed the antiviral activity of various drugs on SARS-CoV …
Tenofovir, another inexpensive, well-known and widely available old drug repurposed for SARS-COV-2 infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is spreading
worldwide with different clinical manifestations. Age and comorbidities may explain severity …
worldwide with different clinical manifestations. Age and comorbidities may explain severity …