The placenta: epigenetic insights into trophoblast developmental models of a generation-bridging organ with long-lasting impact on lifelong health
M Hemberger, W Dean - Physiological Reviews, 2023 - journals.physiology.org
The placenta is a unique organ system that functionally combines both maternal and fetal
cell types with distinct lineage origins. Normal placentation is critical for developmental …
cell types with distinct lineage origins. Normal placentation is critical for developmental …
Shifting early embryology paradigms: Applications of stem cell-based embryo models in bioengineering
A Abel, B Sozen - Current Opinion in Genetics & Development, 2023 - Elsevier
Technologies to reproduce specific aspects of early mammalian embryogenesis in vitro
using stem cells have skyrocketed over the last several years. With these advances, we …
using stem cells have skyrocketed over the last several years. With these advances, we …
Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction
Human naive pluripotent stem cells have unrestricted lineage potential. Underpinning this
property, naive cells are thought to lack chromatin-based lineage barriers. However, this …
property, naive cells are thought to lack chromatin-based lineage barriers. However, this …
KLF17 promotes human naïve pluripotency but is not required for its establishment
RA Lea, A McCarthy, S Boeing, T Fallesen… - …, 2021 - journals.biologists.com
Current knowledge of the transcriptional regulation of human pluripotency is incomplete,
with lack of interspecies conservation observed. Single-cell transcriptomics analysis of …
with lack of interspecies conservation observed. Single-cell transcriptomics analysis of …
The transcriptional regulatory network modulating human trophoblast stem cells to extravillous trophoblast differentiation
During human pregnancy, extravillous trophoblasts play crucial roles in placental invasion
into the maternal decidua and spiral artery remodeling. However, regulatory factors and their …
into the maternal decidua and spiral artery remodeling. However, regulatory factors and their …