Proton pump inhibitor (PPI) use is becoming increasingly common. Although the toxicity
profiles of PPIs are not well understood particularly in children, PPIs have been associated …

Proton pump inhibitors (PPIs) are widely used for acid suppression in the treatment and
prevention of many conditions, including gastroesophageal reflux disease, gastric and …

Gastroesophageal reflux is a common phenomenon in infants, but the differentiation
between gastroesophageal reflux and gastroesophageal reflux disease can be difficult …

Conducting clinical trials in neonates is challenging, and knowledge gaps in neonatal
clinical pharmacology exist. We surveyed the US Food and Drug Administration databases …

Background Studies assessing the appropriate use of proton pump inhibitors (PPIs) for
hospitalized noncritically ill pediatric patients are lacking. Therefore, this study aimed to …

Proton pump inhibitors reduce gastric acid secretion and are commonly utilized in the
management of gastroesophageal reflux disease across all ages. Yet a decrease in lower …

Methods Using the French health insurance data warehouse (SNDS)(2013–2018), we
conducted a retrospective cohort study on singleton, full-term liveborn non …

Objective Proton pump inhibitors are frequently administered on clinical symptoms in
neonates but benefit remains controversial. Clinical trials validating omeprazole dosage in …

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Medications are widely used off-label in pediatrics, including medications intended to treat
gastrointestinal diseases, such as antitumor necrosis factor and laxatives. Although …