Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics

SC Dulawa, DS Janowsky - Molecular psychiatry, 2019 - nature.com
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The
neurobiological mechanisms underlying depression remain poorly understood, although …

Application of citicoline in neurological disorders: a systematic review

P Jasielski, F Piędel, M Piwek, A Rocka, V Petit… - Nutrients, 2020 - mdpi.com
Citicoline is a chemical compound involved in the synthesis of cell membranes. It also has
other, not yet explained functions. Research on the use of citicoline is conducted in …

Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder

RL Dean, C Hurducas, K Hawton… - Cochrane Database …, 2021 - cochranelibrary.com
Background Many studies have recently been conducted to assess the antidepressant
efficacy of glutamate modification in mood disorders. This is an update of a review first …

Does oral administration of ketamine accelerate response to treatment in major depressive disorder? Results of a double-blind controlled trial

S Arabzadeh, E Hakkikazazi, N Shahmansouri… - Journal of affective …, 2018 - Elsevier
Background Major depressive disorder (MDD) exerts a high health and financial burden on
society. The conventional pharmacotherapies for MDD are partially effective and the …

Natural health products, dietary minerals and over-the-counter medications as add-on therapies to antidepressants in the treatment of major depressive disorder: a …

P Dome, L Tombor, J Lazary, X Gonda, Z Rihmer - Brain Research Bulletin, 2019 - Elsevier
Given the moderate efficacy of the currently available antidepressants (ADs) in the treatment
of major depressive disorder (MDD), the identification of agents that are both able to …

Role of citicoline and choline in the treatment of post-stroke depression: an exploratory study

FA Arcadi, F Corallo, M Torrisi, C Scarfì… - Journal of …, 2021 - journals.sagepub.com
Objective To compare selective serotonin reuptake inhibitors (SSRIs) and nootropic drugs in
the reduction of anxiety and depressive symptoms in post-stroke patients. Methods This …

Influence of citicoline on citalopram-induced antidepressant activity in depressive-like symptoms in male mice

M Roohi-Azizi, A Torkaman-Boutorabi… - Physiology & …, 2018 - Elsevier
Depression is associated with significant functional disabilities. Application of new drugs
which could enhance the effectiveness of antidepressants drug and reduce side effects of …

[HTML][HTML] Citicoline improves human vigilance and visual working memory: the role of neuronal activation and oxidative stress

HM Al-Kuraishy, AI Al-Gareeb - Basic and clinical neuroscience, 2020 - ncbi.nlm.nih.gov
Methods: 40 healthy volunteers were enrolled and divided into two groups: group A: 20
volunteers received 500mg/day starch capsule for two weeks and group B: 20 volunteers …

Synergistic effect between citalopram and citicoline on anxiolytic effect in non-sensitized and morphine-sensitized mice: an isobologram analysis

S Nejati, F Khakpai, MR Zarrindast - Brain research, 2020 - Elsevier
In the present study, the effects of intraperitoneal (ip) injections of citalopram and citicoline
on morphine-induced anxiolytic effects were investigated in non-sensitized and morphine …

Structure-based discovery of dual-target inhibitors of the helicase from bagaza virus

R Zhao, W Shu, WS Hu, C Chen, JY Ning, J Luo… - International Journal of …, 2025 - Elsevier
Bagaza virus (BAGV) is a mosquito-borne flavivirus and has caused significant avian death
in many regions, and also garnered recognition as a significant human pathogen causing …