T cells are critical in orchestrating protective immune responses to cancer and an array of
pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting …

Autoimmune diseases (ADs) showcase the intricate balance between the immune system's
protective functions and its potential for self-inflicted damage. These disorders arise from the …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
caused by CNS-infiltrating leukocytes, including TH17 cells that are critical mediators of …

Interference with immune cell proliferation represents a successful treatment strategy in T
cell–mediated autoimmune diseases such as rheumatoid arthritis and multiple sclerosis …

Both higher-and lower-affinity self-reactive CD4+ T cells are expanded in autoimmunity;
however, their individual contribution to disease remains unclear. We addressed this …

Autoreactive encephalitogenic T cells exist in the healthy immune repertoire but need a
trigger to induce CNS inflammation. The underlying mechanisms remain elusive, whereby …

Abstract αβ T cell antigen receptors (TCRs) bind complexes of peptide and major
histocompatibility complex (pMHC) with low affinity, which poses a considerable challenge …

We have recently shown that two-dimensional (2D) and force-regulated kinetics of TCR–
peptide-bound MHC class I (pMHC-I) interactions predict responses of CD8+ T cells. To test …

To study T cell activation in vivo in real time, we introduced a newly developed fluorescence
resonance energy transfer–based, genetically encoded calcium indicator into autoantigen …

T cells are key players of the mammalian adaptive immune system. They experience
different mechanical microenvironments during their life cycle, from the thymus, secondary …