Myeloproliferative neoplasms: from origins to outcomes
J Nangalia, AR Green - Hematology 2014, the American …, 2017 - ashpublications.org
Substantial progress has been made in our understanding of the pathogenetic basis of
myeloproliferative neoplasms. The discovery of mutations in JAK2 over a decade ago …
myeloproliferative neoplasms. The discovery of mutations in JAK2 over a decade ago …
The role of ASXL1 in hematopoiesis and myeloid malignancies
S Asada, T Fujino, S Goyama, T Kitamura - Cellular and molecular life …, 2019 - Springer
Recent high-throughput genome-wide sequencing studies have identified recurrent somatic
mutations in myeloid neoplasms. An epigenetic regulator, Additional sex combs-like 1 …
mutations in myeloid neoplasms. An epigenetic regulator, Additional sex combs-like 1 …
Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies
Abstract Additional Sex Combs-Like 1 (ASXL1) is mutated at a high frequency in all forms of
myeloid malignancies associated with poor prognosis. We generated a Vav1 promoter …
myeloid malignancies associated with poor prognosis. We generated a Vav1 promoter …
Epigenetic regulators as the gatekeepers of hematopoiesis
CP Rodrigues, M Shvedunova, A Akhtar - Trends in Genetics, 2021 - cell.com
Hematopoiesis is the process by which both fetal and adult organisms derive the full
repertoire of blood cells from a single multipotent progenitor cell type, the hematopoietic …
repertoire of blood cells from a single multipotent progenitor cell type, the hematopoietic …
SMC1A regulated by KIAA1429 in m6A-independent manner promotes EMT progress in breast cancer
X Zhang, XY Dai, JY Qian, F Xu, ZW Wang, T Xia… - … Therapy-Nucleic Acids, 2022 - cell.com
As a component of N6-methyladenosine (m6A)" writers," KIAA1429 was reported to promote
breast cancer proliferation and growth in m6A-independent manners. However, the related …
breast cancer proliferation and growth in m6A-independent manners. However, the related …
Combined Cohesin–RUNX1 deficiency synergistically perturbs chromatin looping and causes myelodysplastic syndromes
STAG2 encodes a cohesin component and is frequently mutated in myeloid neoplasms,
showing highly significant comutation patterns with other drivers, including RUNX1 …
showing highly significant comutation patterns with other drivers, including RUNX1 …
ASXL1/2 mutations and myeloid malignancies
EA Medina, CR Delma, FC Yang - Journal of Hematology & Oncology, 2022 - Springer
Myeloid malignancies develop through the accumulation of genetic and epigenetic
alterations that dysregulate hematopoietic stem cell (HSC) self-renewal, stimulate HSC …
alterations that dysregulate hematopoietic stem cell (HSC) self-renewal, stimulate HSC …
Targeting lysine demethylase 6B ameliorates ASXL1 truncation–mediated myeloid malignancies in preclinical models
ASXL1 mutation frequently occurs in all forms of myeloid malignancies and is associated
with aggressive disease and poor prognosis. ASXL1 recruits Polycomb repressive complex …
with aggressive disease and poor prognosis. ASXL1 recruits Polycomb repressive complex …
DNA methylation signature associated with Bohring-Opitz syndrome: a new tool for functional classification of variants in ASXL genes
Z Awamleh, E Chater-Diehl, S Choufani… - European Journal of …, 2022 - nature.com
The additional sex combs-like (ASXL) gene family—encoded by ASXL1, ASXL2, and ASXL3—
is crucial for mammalian development. Pathogenic variants in the ASXL gene family are …
is crucial for mammalian development. Pathogenic variants in the ASXL gene family are …
Cohesin mutations in acute myeloid leukemia
A Boucher, J Murray, S Rao - Leukemia, 2024 - nature.com
The cohesin complex, encoded by SMC3, SMC1A, RAD21, and STAG2, is a critical
regulator of DNA-looping and gene expression. Over a decade has passed since recurrent …
regulator of DNA-looping and gene expression. Over a decade has passed since recurrent …