Copper (I)-catalyzed 1, 3-dipolar cycloaddition between organic azides and terminal
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …

It has been amply constated that sugar ligand multivalency increases lectin-binding avidities
dramatically, thereby modulating the capacity of carbohydrates to participate in …

Iminosugars are naturally occurring carbohydrate analogues known since 1967. These
natural compounds and hundreds of their synthetic derivatives prepared over five decades …

Pharmaceutical chaperones (PCs) are small compounds able to bind and stabilize
misfolded proteins, allowing them to recover their native folding and thus their biological …

Glycosidases are ubiquitous enzymes involved in a diversity of key biological processes
such as energy uptake or cell wall degradation. The design of specific glycosidase inhibitors …

Hexa-substituted fullerenes are unique scaffolds for the fast construction of globular
dendrimers. Efficient synthetic methodologies based on the post-functionalization of pre …

In 2004 we first reported catalytic nanoparticles, that are able to cleave phosphate diesters
with very high efficiency (Angew. Chem. Int Ed, 2004, 43, 6165–6169) and dubbed them …

The last decade has witnessed a series of discoveries that question the traditional paradigm
of multivalency as a “safe” strategy to enhance the binding affinity of a lectin receptor to its …

Multivalent design of glycosidase inhibitors is a promising strategy for the treatment of
diseases involving enzymatic hydrolysis of glycosidic bonds in carbohydrates. An essential …

Iminosugars are sugar analogues endowed with a high pharmacological potential. The wide
range of biological activities exhibited by these glycomimetics associated with their excellent …