Recent developments in 1, 6-addition reactions of para-quinone methides (p-QMs)

JY Wang, WJ Hao, SJ Tu, B Jiang - Organic Chemistry Frontiers, 2020 - pubs.rsc.org
In recent years, para-quinone methides (p-QMs) have emerged as attractive and versatile
synthons in organic synthesis owing to their high reactivity. Consequently, p-QM chemistry …

para‐Quinone Methides as Acceptors in 1,6‐Nucleophilic Conjugate Addition Reactions for the Synthesis of Structurally Diverse Molecules

CGS Lima, FP Pauli, DCS Costa… - European Journal of …, 2020 - Wiley Online Library
para‐Quinone methides (p‐QMs) are naturally occurring molecules that have been finding
increasing synthetic applications in the last few years. The presence of two electronically …

Construction of Oxygen‐ and Nitrogen‐based Heterocycles from p‐Quinone Methides

G Singh, R Pandey, YA Pankhade, S Fatma… - The Chemical …, 2021 - Wiley Online Library
In the last few years, there has been an explosive growth in the area of para‐quinone
methide (p‐QM) chemistry. This boom is actually due to the unique reactivity pattern of p …

P(NMe2)3-Mediated Umpolung Spirocyclopropanation Reaction of p-Quinone Methides: Diastereoselective Synthesis of Spirocyclopropane-Cyclohexadienones

YH Deng, WD Chu, YH Shang, KY Yu, ZL Jia… - Organic …, 2020 - ACS Publications
An unprecedented umpolung spirocyclopropanation reaction of p-quinone methides and α-
keto carbonyls is described. Our umpolung strategy based on 1, 6-conjugate addition and …

Olefin skeletal rearrangement enabling access to multiarylated N-sulfonyl amidines

CC Cui, F Lin, LY Wang, YP Liu, SJ Tu, MS Tu… - Chemical …, 2024 - pubs.rsc.org
A base-promoted olefin skeletal rearrangement strategy from para-quinone methides (p-
QMs) and N-fluoroarenesulfonamides is reported, enabling direct nitrogen insertion of …

A thermal decarboxylative Cloke–Wilson rearrangement of dispirocyclopropanes derived from para-quinone methides and bromo-Meldrum's acids: an approach to …

T Li, D Yan, C Cui, X Song, J Chang - Organic Chemistry Frontiers, 2020 - pubs.rsc.org
An unprecedented approach to synthesize spirobutyrolactone para-dienones from para-
quinone methides and bromo-Meldrum's acids has been developed. A series of spatially …

Divergent synthesis of oxindole derivatives via controllable reactions of isatin-derived para-quinone methides with sulfur ylides

Y You, BX Quan, ZH Wang, JQ Zhao… - Organic & Biomolecular …, 2020 - pubs.rsc.org
A catalyst-free and controllable reaction of isatin-derived para-quinone methides with sulfur
ylides was developed. This protocol enables the divergent synthesis of two different …

Stereoselective Sequential Spirocyclopropanation/Cloke–Wilson Rearrangement Reactions for Synthesis of trans-β,γ-Disubstituted γ-Butyrolactones Using …

M Zhang, T Li, C Cui, X Song… - The Journal of Organic …, 2020 - ACS Publications
The stereoselective sequential spirocyclopropanation/Cloke–Wilson rearrangement
reactions have been developed to synthesize γ-butyrolactones using alkylidene Meldrum's …

1, 6-Addition of vinyl p-quinone methides with cyclic sulfamidate imines: access to 4-hydroxyaryl-2, 6-diarylpyridines

S Guin, SK Gudimella, S Samanta - Organic & Biomolecular Chemistry, 2020 - pubs.rsc.org
A simple and powerful one-pot regioselective 1, 6-addition elimination–6π-aza-
electrocyclization–aromatization reaction of vinyl/dienyl-substituted para-quinone methides …

C2-Arylated Indoles and Benzofurans through Formal (4 + 1) Annulation of N-Sulfonyl-2-aminobenzaldehydes and Salicylaldehyde Derivatives with Electron …

LA de Ceuninck van Capelle… - The Journal of …, 2024 - ACS Publications
A two-step formal (4+ 1) annulation-dehydration reaction offers a convenient route to C2-
arylated indoles and benzofurans. This reaction exploits the bifunctional reactivity of electron …