Drugs that kill tumors through multiple mechanisms have the potential for broad clinical
benefits. Here, we first developed an in silico multiomics approach (BipotentR) to find cancer …

Overexpression of androgen receptor (AR) is the primary cause of castration-resistant
prostate cancer, although mechanisms upregulating AR transcription in this context are not …

Aims Haploinsufficiency of the chromo-domain protein CHD7 underlies most cases of
CHARGE syndrome, a multisystem birth defect including congenital heart malformation …

Abstract Background The Zic family of transcription factors (TFs) promote both proliferation
and maturation of cerebellar granule neurons (CGNs), raising the question of how a single …

Motivation Our study aimed to identify biologically relevant transcription factors (TFs) that
control the expression of a set of co-expressed or co-regulated genes. Results We …

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are advancing
cardiovascular development and disease modeling, drug testing, and regenerative …

Background Suicide is a leading cause of death globally. Identifying individuals at higher
suicidal risk is a key to suicide prevention. Patients with comorbid psychiatric disorders …

Alterations in three-dimensional (3D) genome structures are associated with cancer 1–5.
However, how genome folding evolves and diversifies during subclonal cancer progression …

Dysregulation of gene expression plays an important role in cancer development. Identifying
transcriptional regulators, including transcription factors and chromatin regulators, that drive …

Background Adult hippocampal neurogenesis (AHN) is a clinically significant neural
phenomenon. Understanding its molecular regulation would be important. In this regard …