Macrophages and neutrophils are key components involved in the regulation of numerous
chronic inflammatory diseases, infectious disorders, and especially certain autoimmune …

The Runx family of transcription factors (Runx1, Runx2, and Runx3) are highly conserved
and encode proteins involved in a variety of cell lineages, including blood and blood-related …

Efforts to derive hematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs)
are complicated by the fact that embryonic hematopoiesis consists of two programs, primitive …

Reconstruction of the molecular pathways controlling organ development has been
hampered by a lack of methods to resolve embryonic progenitor cells. Here we describe a …

Human pluripotent stem cells (hPSCs) provide an unparalleled opportunity to establish in
vitro differentiation models that will transform our approach to the study of human …

Highlights•Primitive hematopoiesis encompasses the earliest wave of blood emergence,
occurring at approximately E7. 25 in the yolk sac.•There is still no conclusive in vivo …

Haematopoietic stem cells (HSCs) are tissue-specific stem cells that replenish all mature
blood lineages during the lifetime of an individual. Clinically, HSCs form the foundation of …

The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells
(hPSCs) is a major goal for regenerative medicine. During embryonic development, HSCs …

The first adult-repopulating hematopoietic stem cells (HSCs) emerge in the aorta-gonads-
mesonephros (AGM) region of the embryo. We have recently identified the transcription …

The transcription factor Runx1 is essential for the formation of yolk sac-derived
erythroid/myeloid progenitors (EMPs) and hematopoietic stem cells (HSCs) from hemogenic …