Functionalized benzimidazole scaffolds: privileged heterocycle for drug design in therapeutic medicine

OO Ajani, DV Aderohunmu, CO Ikpo… - Archiv der …, 2016 - Wiley Online Library
Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of
biologically active compounds which are therapeutically useful agents in drug discovery and …

CircRNA CBL. 11 suppresses cell proliferation by sponging miR-6778-5p in colorectal cancer

H Li, X Jin, B Liu, P Zhang, W Chen, Q Li - BMC cancer, 2019 - Springer
Background Radiotherapy (RT) is considered an important therapeutic strategy in the fight
against colorectal cancer (CRC). However, the existence of some radioresistance factors …

Radiation sensitivity of biological systems, its modification by chemical modifiers and its quantitative evaluation

V Múčka, V Čuba - Journal of Radioanalytical and Nuclear Chemistry, 2024 - Springer
Large number of sensitizers and protectors of cells, tissues, organs and organisms are being
discussed in this review. Attention is paid to metals, nanoparticles or organic compounds as …

Akt1/NFκB signaling pathway activation by a small molecule DMA confers radioprotection to intestinal epithelium in xenograft model

V Tiwari, MZ Kamran, A Ranjan, H Nimesh… - Free Radical Biology …, 2017 - Elsevier
Normal tissue protection and recovery of radiation-induced damage are of paramount
importance for development of radioprotector. Radioprotector which selectively protects …

DMA, a Small Molecule, Increases Median Survival and Reduces Radiation-Induced Xerostomia via the Activation of the ERK1/2 Pathway in Oral Squamous Cell …

P Parashar, MK Das, P Tripathi, T Kataria, D Gupta… - Cancers, 2022 - mdpi.com
Simple Summary Radiotherapy is commonly used to treat the majority of patients with head
and neck cancers. Salivary glands in the radiation field are affected by this procedure. The …

DMA, a bis-benzimidazole, confers radioprotection to the intestine via Akt/NFκB dual pathway activation

V Tiwari, V Tandon - US Patent 10,016,515, 2018 - Google Patents
The present invention relates to dual activation of Akt/NFκB pathway by DMA (5-(4-
methylpiperazin-1-yl)-2-[2′-(3, 4-dimethoxyphenyl)-5′-benzimidazolyl] benzimidazole) to …

[PDF][PDF] Faculty Details proforma for DU Web-site

OP No, C Profile - development, 2010 - xn--e2b2a0cj.xn--j2bsq2bc9f.xn …
Faculty Details proforma for DU Web-site Page 1 www.du.ac.in Page 1 Title Dr. First Name
Kennedy Singh Last Name Moirangthe m Photograph Designation Assistant Professor Address …

[引用][C] Preclinical evaluation of DMA, a bisbenzimidazole, as radioprotector: Toxicity, pharmacokinetics, and biodistribution studies in Balb/c mice

H Nimesh, V Tiwari, C Yang, SR Gundala… - Molecular …, 2015 - ASPET