AMPA receptor neurotransmission and therapeutic applications: A comprehensive review of their multifaceted modulation

M Qneibi, S Bdir, M Bdair, SA Aldwaik… - European Journal of …, 2024 - Elsevier
The neuropharmacological community has shown a strong interest in AMPA receptors as
critical components of excitatory synaptic transmission during the last fifteen years. AMPA …

Quinoxaline-based chromogenic and fluorogenic chemosensors for the detection of metal cations

LC da Silva, VG Machado, FG Menezes - Chemical Papers, 2021 - Springer
The development of molecular and supramolecular optical devices for sensing ionic
analytes in solution has emerged as a promissory field in the last decades. In this context …

Effect of pH on the efficiency of sodium hexametaphosphate as calcium carbonate scale inhibitor at high temperature and high pressure

SC de Morais, DF de Lima, TM Ferreira, JB Domingos… - Desalination, 2020 - Elsevier
Calcium carbonate (CaCO 3) scale deposition causes serious issues in industries which
deal with water, and its formation reaction is pH-depending. This study investigated the …

Combined NMR Spectroscopy and Quantum-Chemical Calculations in Fluorescent 1, 2, 3-Triazole-4-carboxylic Acids Fine Structures Analysis

NE Safronov, IP Kostova, MA Palafox… - International Journal of …, 2023 - mdpi.com
The peculiarities of the optical properties of 2-aryl-1, 2, 3-triazole acids and their sodium
salts were investigated in different solvents (1, 4-dioxane, dimethyl sulfoxide DMSO …

Quinoxaline-functionalized silver nanoparticles as chromogenic probe for the multiple selective detection of cysteine, Mg2+ and Sn2+ in aqueous solution

JM Neri, E Latocheski, JGL de Araújo… - Sensors and Actuators B …, 2021 - Elsevier
Herein we report the successful synthesis of stable silver nanoparticles (AgNPs) using 1, 1′-
(quinoxaline-2, 3-diylbis (azanediyl)) diethanol (QX) as the only stabilizer. The QX-AgNPs …

Experimental and computational study of the pKa of coumaric acid derivatives

A Benvidi, A Dadras, S Abbasi… - Journal of the …, 2019 - Wiley Online Library
The dissociation constant (pKa) of a drug is a key parameter in drug discovery and
pharmaceutical formulation. The hydroxy substituent has a significant effect on the acidity of …

[HTML][HTML] Multicomponent synthesis of substituted 3-styryl-1H-quinoxalin-2-ones in an aqueous medium

EP da Costa, SE Coelho, AH de Oliveira, RM Araújo… - Tetrahedron …, 2018 - Elsevier
A multicomponent synthesis of substituted 3-styryl-1H-quinoxalin-2-ones is described.
Sequential reactions of o-phenylenediamine with sodium pyruvate and aldehydes in 20 …

Quinoxalinedione deprotonation is important for glutamate receptor binding

A Dudić, A Reiner - Biological Chemistry, 2019 - degruyter.com
Quinoxalinediones are an important class of competitive antagonists at ionotropic glutamate
receptors (iGluRs), where they are widely used to block α-amino-3-hydroxy-5-methyl-4 …

Anticancer, anti-inflammatory and analgesic activities of aminoalcohol-based quinoxaline small molecules

JM Neri, PEA Siqueira, ALCSL Oliveira… - Acta Cirúrgica …, 2024 - SciELO Brasil
Purpose: Bioactive molecules are relevant to fight cancer and associated conditions.
Quinoxaline is a privileged N-heterocycle, notably as anticancer agents. Herein, we report …

[HTML][HTML] Prospecting native and analogous peptides with anti-SARS-CoV-2 potential derived from the trypsin inhibitor purified from tamarind seeds

ABS Luz, AF de Medeiros, LL Bezerra… - Arabian Journal of …, 2023 - Elsevier
The study aimed to prospect in silico native and analogous peptides with anti-SARS-CoV-2
potential derived from the trypsin inhibitor purified from tamarind seeds (TTIp). From the most …