Natural scaffolds remain an important basis for drug development. Therefore, approaches to
natural bioactive compound discovery attract significant attention. In this account, we …

A targeted and logical discovery method was devised for natural products containing
piperazic acid (Piz), which is biosynthesized from ornithine by l-ornithine N-hydroxylase …

This mini-review covers the use of nitrogen-15 in bacterial and fungal natural product
discovery and biosynthetic characterization from 1970 to 2022. Nitrogen is an important …

Abstract β-Amino acid-containing macrolactams represent a structurally diverse group of
bioactive natural products derived from polyketides; however we are currently lacking a …

Natural products (NPs), are small molecules produced naturally by any organism. As they
may be isolated in small quantities, having interesting biological activities and lush chemical …

A targeted metabologenomic method was developed to selectively discover terminal
oxazole‐bearing natural products from bacteria. For this, genes encoding oxazole cyclase, a …

Macrolactam antibiotics incorporating β-amino acid polyketide starter units, isolated
primarily from Actinomycetes species, show significant biological activities. This review …

Twelve new polyenic macrolactams, cyclamenols G–R (1 and 3–13), together with the
known analogue cyclamenol A (2), were isolated from Streptomyces sp. OUCMDZ-4348 …

Heat-stable antifungal factor (HSAF) produced by the biocontrol bacterium Lysobacter
enzymogenes shows considerable antifungal activity and has broad application potential in …

Natural alkaloids originating from actinomycetes and synthetic derivatives have always been
among the important suppliers of small-molecule drugs. Among their biological sources …