Simple Summary The approval of combination treatments such as chemoimmunotherapy
was a breakthrough in managing chronic lymphocytic leukemia and small lymphocytic …

The knowledge of chronic lymphocytic leukemia (CLL) has progressively deepened during
the last forty years. Research activities and clinical studies have been remarkably fruitful in …

Chromosome 14q32 rearrangements/translocations involving the immunoglobulin heavy
chain (IGH) are rarely detected in chronic lymphocytic leukemia (CLL). The prognostic …

BIRC3 is monoallelically deleted in up to 80% of chronic lymphocytic leukemia (CLL) cases
harboring del (11q). In addition, truncating mutations in the remaining allele of this gene can …

CRISPR-Cas9 gene editing has transformed our ability to rapidly interrogate the functional
impact of somatic mutations in human cancers. Droplet-based technology enables the …

Rapid advances in large-scale next-generation sequencing studies of human samples have
progressively defined the highly heterogeneous genetic landscape of chronic lymphocytic …

Simple Summary The p53 pathway plays a fundamental role in preventing the accumulation
of unrepaired DNA damage. Unsurprisingly, cancer cells often break this protective barrier …

Simple Summary Chronic lymphocytic leukemia (CLL) is characterized by a highly variable
clinical course. Thus, predicting the outcome of patients with this disease is a topic of special …

Simple Summary High-throughput CRISPR screening provides an unbiased way for
functional genomic studies in hematological malignancies. This approach has been used to …

Although the chronic lymphocytic leukemia (CLL) treatment landscape has changed
dramatically, unmet clinical needs are emerging, as CLL in many patients does not respond …