This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …

The detrusor smooth muscle is the main muscle component of the urinary bladder wall. Its
ability to contract over a large length interval and to relax determines the bladder function …

Work performed with differentiated contractile smooth muscle tissue over the last two
decades has made clear that covalent modification of myosin by phosphorylation of the 20 …

Resolving the distribution of specific proteins at the nanoscale in the ultrastructural context of
the cell is a major challenge in fluorescence microscopy. We report the discovery of a new …

A growing body of data supports a view of the actin cytoskeleton of smooth muscle cells as a
dynamic structure that plays an integral role in regulating the development of mechanical …

• Introduction• Mechanisms that regulate LC20 phosphorylation‐Regulation of myosin
phosphatase‐CaMKII• Mechanisms that regulate the access of myosin to actin‐Caldesmon …

Morphological, functional, molecular and cell biology studies have revealed a striking
multifunctional nature of individual smooth muscle cells (SMC). SMCs manifest phenotypic …

Smooth muscle cells (SMC) exhibit a functional plasticity, modulating from the mature
phenotype in which the primary function is contraction, to a less differentiated state with …

Actin, one of the main proteins of muscle and cytoskeleton, exists as a vaiety of highly
conserved isoforms whose distribution in vertebrates is tissue-specific. Synthesis of specific …