DNA viruses are linked to many infectious diseases and contribute significantly to human
morbidity and mortality worldwide. Moreover, DNA viral infections are usually lifelong and …

Increased sensitivity of cancer cells to viruses is a prerequisite for the success of oncolytic
virotherapy. One of the major causes of such a phenotype is the disruption of innate antiviral …

Summary Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that plays a critical
role in regulating antiviral signaling. cGAS binds to DNA and catalyzes the synthesis of …

DNA damage is typically caused during cell growth by DNA replication stress or exposure to
endogenous or external toxins. The accumulation of damaged DNA causes genomic …

Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of a neural chronic
inflammation, called HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) …

Mediator of IRF3 activation (MITA, also named as STING/ERIS/MPYS/TMEM173), is
essential to DNA virus-or cytosolic DNA-triggered innate immune responses. In this study …

Virus infection is sensed by pattern recognition receptors (PRRs) detecting virus nucleic
acids and initiating an innate immune response. DNA-dependent protein kinase (DNA-PK) …

Toll-like receptors (TLRs) are key pattern recognition receptors that mediate innate immune
responses to infection. However, uncontrolled TLR activation can lead to severe …

Since its discovery in 1981, the Ku complex has been extensively studied under multiple
cellular contexts, with most work focusing on Ku in terms of its essential role in non …

Human Ku70 is a well-known endogenous nuclear protein involved in the non-homologous
end joining pathway to repair double-stranded breaks in DNA. However, Ku70 has been …