Many processes in the regulation of gene expression and signaling involve the formation of
protein complexes involving multi-domain proteins. Individual domains that mediate protein …

We determined the solution structure of myristoylated Mason-Pfizer monkey virus matrix
protein by NMR spectroscopy. The myristoyl group is buried inside the protein and causes a …

For most retroviruses, including HIV, association with the plasma membrane (PM) promotes
the assembly of immature particles, which occurs simultaneously with budding and …

The Spumaretrovirinae, or foamyviruses (FVs) are complex retroviruses that infect many
species of monkey and ape. Although FV infection is apparently benign, trans-species …

Matrix proteins play multiple roles both in early and late stages of the viral replication cycle.
Their N-terminal myristoylation is important for interaction with the host cell membrane …

Background Myristoylation of the matrix (MA) domain mediates the transport and binding of
Gag polyproteins to the plasma membrane (PM) and is required for the assembly of most …

Retroviral Gag polyproteins are targeted to the inner leaflet of the plasma membrane
through their N-terminal matrix (MA) domain. Because retroviruses of different …

Retroviral envelope glycoprotein (Env) is essential for the specific recognition of the host cell
and the initial phase of infection. As reported for human immunodeficiency virus (HIV), the …

The oligomerization capacity of the retroviral matrix protein is an important feature that
affects assembly of immature virions and their interaction with cellular membrane. A …

ABSTRACT The Mason–Pfizer monkey virus is a type D retrovirus, which assembles its
immature particles in the cytoplasm prior to their transport to the host cell membrane. The …