Helminth parasites infect almost one-third of the world's population, primarily in tropical
regions. However, regions where helminth parasites are endemic record much lower …

Immunology was founded by studying the body's response to infectious microorganisms,
and yet microbial prokaryotes only tell half the story of the immune system. Eukaryotic …

Helminth parasites are highly prevalent in human communities in developing countries. In
an endemic area an infected individual may harbour parasitic worms for most of his or her …

Human filarial parasites cause chronic infection associated with long-term down-regulation
of the host's immune response. We show here that CD4+ T cell regulation is the main …

Although exogeneous “danger” signals such as LPS can activate APC to produce a Th1
response, the nature of events initiating a Th2 response is controversial. We now show that …

The identification of crossregulating T helper (Th) cells has revolutionized current
understanding of the immune response to infection. While paying tribute to this revolution …

Infectious agents have intimately co-evolved with the host immune system, acquiring a
portfolio of highly sophisticated mechanisms to modulate immunity. Among the common …

Helminth parasites have large genomes (~ 108 bp) which are likely to encode a spectrum of
products able to block or divert the host immune response. We have employed three parallel …

To determine whether counterregulation by interleukin (IL)-10 plays a role in the generation
or maintenance of the antigen-specific hyporesponsiveness seen in asymptomatic …

Parasitic infections are a major theme in the “hygiene hypothesis”, as allergies and
autoimmune diseases are less prevalent in countries with higher burdens of helminths and …