[HTML][HTML] G protein-coupled receptors in taste physiology and pharmacology
R Ahmad, JE Dalziel - Frontiers in pharmacology, 2020 - frontiersin.org
Heterotrimeric G protein-coupled receptors (GPCRs) comprise the largest receptor family in
mammals and are responsible for the regulation of most physiological functions. Besides …
mammals and are responsible for the regulation of most physiological functions. Besides …
[HTML][HTML] Allostery in its many disguises: from theory to applications
Allosteric regulation plays an important role in many biological processes, such as signal
transduction, transcriptional regulation, and metabolism. Allostery is rooted in the …
transduction, transcriptional regulation, and metabolism. Allostery is rooted in the …
BitterDB: taste ligands and receptors database in 2019
A Dagan-Wiener, A Di Pizio, I Nissim… - Nucleic Acids …, 2019 - academic.oup.com
Abstract BitterDB (http://bitterdb. agri. huji. ac. il) was introduced in 2012 as a central
resource for information on bitter-tasting molecules and their receptors. The information in …
resource for information on bitter-tasting molecules and their receptors. The information in …
[HTML][HTML] The endocannabinoid system as a target in cancer diseases: are we there yet?
The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …
decade. The immense data load published on its dual role in both tumorigenesis and …
Bitter taste receptor activation by cholesterol and an intracellular tastant
Bitter taste sensing is mediated by type 2 taste receptors (TAS2Rs (also known as T2Rs)),
which represent a distinct class of G-protein-coupled receptors. Among the 26 members of …
which represent a distinct class of G-protein-coupled receptors. Among the 26 members of …
Sweet, umami and bitter taste receptors: State of the art of in silico molecular modeling approaches
G Spaggiari, A Di Pizio, P Cozzini - Trends in food science & technology, 2020 - Elsevier
Background The human taste experience is the result of five basic taste qualities, namely
sweet, salty, bitter, sour and umami. Sweet, bitter, and umami are mediated by G protein …
sweet, salty, bitter, sour and umami. Sweet, bitter, and umami are mediated by G protein …
Classification model for the second extracellular loop of class A GPCRs
A Nicoli, A Dunkel, T Giorgino, C de Graaf… - Journal of Chemical …, 2022 - ACS Publications
The extracellular loop 2 (ECL2) is the longest and the most diverse loop among class AG
protein-coupled receptors (GPCRs). It connects the transmembrane (TM) helices 4 and 5 …
protein-coupled receptors (GPCRs). It connects the transmembrane (TM) helices 4 and 5 …
[HTML][HTML] Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor ligands
F Fierro, L Peri, H Hübner, A Tabor-Schkade… - Cellular and Molecular …, 2023 - Springer
The human GPCR family comprises circa 800 members, activated by hundreds of thousands
of compounds. Bitter taste receptors, TAS2Rs, constitute a large and distinct subfamily …
of compounds. Bitter taste receptors, TAS2Rs, constitute a large and distinct subfamily …
[HTML][HTML] On the human taste perception: Molecular-level understanding empowered by computational methods
Background The perception of taste is a prime example of complex signal transduction at the
subcellular level, involving an intricate network of molecular machinery, which can be …
subcellular level, involving an intricate network of molecular machinery, which can be …
Bitter taste receptors: Novel insights into the biochemistry and pharmacology
A Jaggupilli, R Howard, JD Upadhyaya… - The international journal …, 2016 - Elsevier
Bitter taste receptors (T2Rs) belong to the super family of G protein-coupled receptors
(GPCRs). There are 25 T2Rs expressed in humans, and these interact with a large and …
(GPCRs). There are 25 T2Rs expressed in humans, and these interact with a large and …