Global epidemiology of cirrhosis—aetiology, trends and predictions
Cirrhosis is an important cause of morbidity and mortality in people with chronic liver
disease worldwide. In 2019, cirrhosis was associated with 2.4% of global deaths. Owing to …
disease worldwide. In 2019, cirrhosis was associated with 2.4% of global deaths. Owing to …
Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy
Hepatic encephalopathy (HE) is a frequent and serious complication of both chronic liver
disease and acute liver failure. HE manifests as a wide spectrum of neuropsychiatric …
disease and acute liver failure. HE manifests as a wide spectrum of neuropsychiatric …
Acute-on-chronic liver failure clinical guidelines
In patients with cirrhosis and chronic liver disease, acute-on-chronic liver failure is emerging
as a major cause of mortality. These guidelines indicate the preferred approach to the …
as a major cause of mortality. These guidelines indicate the preferred approach to the …
[HTML][HTML] The microbiota in cirrhosis and its role in hepatic decompensation
J Trebicka, J Macnaughtan, B Schnabl… - Journal of …, 2021 - Elsevier
Cirrhosis–the common end-stage of chronic liver disease–is associated with a cascade of
events, of which intestinal bacterial overgrowth and dysbiosis are central. Bacterial toxins …
events, of which intestinal bacterial overgrowth and dysbiosis are central. Bacterial toxins …
EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis
P Angeli, M Bernardi, C Villanueva, C Francoz… - Journal of …, 2018 - Elsevier
The natural history of cirrhosis is characterised by an asymptomatic compensated phase
followed by a decompensated phase, marked by the development of overt clinical signs, the …
followed by a decompensated phase, marked by the development of overt clinical signs, the …
Comparison of mortality risk in patients with cirrhosis and COVID-19 compared with patients with cirrhosis alone and COVID-19 alone: multicentre matched cohort
Objective Comorbid conditions are associated with poor prognosis in COVID-19. Registry
data show that patients with cirrhosis may be at high risk. However, outcome comparisons …
data show that patients with cirrhosis may be at high risk. However, outcome comparisons …
Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis
G Mezzano, A Juanola, A Cardenas, E Mezey… - Gut, 2022 - gut.bmj.com
Background and aims Acute-on-chronic liver failure (ACLF) is characterised by acute
decompensation of cirrhosis associated with organ failures. We systematically evaluated the …
decompensation of cirrhosis associated with organ failures. We systematically evaluated the …
Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure
The human gut microbiome has emerged as a major player in human health and disease.
The liver, as the first organ to encounter microbial products that cross the gut epithelial …
The liver, as the first organ to encounter microbial products that cross the gut epithelial …
Acute-on-chronic liver failure
Acute-on-Chronic Liver Failure Acute decompensation in patients with chronic liver disease
is called acute-on-chronic liver failure. Usually, systemic inflammation from infection or an …
is called acute-on-chronic liver failure. Usually, systemic inflammation from infection or an …
[HTML][HTML] Acute-on-chronic liver failure: definitions, pathophysiology and principles of treatment
G Zaccherini, E Weiss, R Moreau - JHEP Reports, 2021 - Elsevier
The term acute-on-chronic liver failure (ACLF) defines an abrupt and life-threatening
worsening of clinical conditions in patients with cirrhosis or chronic liver disease. In recent …
worsening of clinical conditions in patients with cirrhosis or chronic liver disease. In recent …