ABC (ATP-binding cassette) transporters represent one of the largest and most diverse
superfamily of proteins in living species, playing an important role in many biological …

The strength of the blood-brain barrier (BBB) in providing protection to the central nervous
system from exposure to circulating chemicals is maintained by tight junctions between …

Abstract P-glycoprotein (ABCB1, MDR1) belongs to the ABC transporter family transporting
a wide range of drugs and xenobiotics from intra-to extracellular at many biological …

Introduction Interindividual differences in drug response are a frequent clinical challenge
partly due to variation in pharmacokinetics. ATP-binding cassette (ABC) transporters are …

There is high variability in the response to antiepileptic treatment across people with
epilepsy. Genetic factors significantly contribute to such variability. Recent advances in the …

Multi-drug chemoresistance remains one of the most common reasons for chemotherapy
failure. The membrane transporter protein ABCG2/BCRP1 has been shown in vitro to …

Drug-resistant epilepsy (DRE) affects approximately one third of epileptic patients. Among
various theories that try to explain multidrug resistance, the transporter hypothesis is the …

Over-expression of drug efflux transporters at the level of the blood–brain barrier (BBB) has
been proposed as a mechanism responsible for multidrug resistance. Drug transporters in …

OBJECTIVE: The C3435T, a major allelic variant of the ABCB1 gene, is proposed to play a
crucial role in drug-resistance in epilepsy. The C/C genotype carriers reportedly are at …

Aims: Some study found that ATP‐binding cassette (ABC) efflux transporters play an
important role in antiepileptic drug resistance, especially ABCB1 and ABCC2. The aims of …