Cadherin family includes lists of transmembrane glycoproteins which mediate calcium-
dependent cell-cell adhesion. Cadherin-mediated adhesion regulates cell growth and …

Inhibitory MHC class I receptors were initially described on natural killer (NK) cells, where
they participate in inducing NK-cell self-tolerance. Inhibitory NK-cell receptors (iNKRs) can …

CD4+ cytotoxic T lymphocytes (CD4-CTLs) have been reported to play a protective role in
several viral infections. However, little is known in humans about the biology of CD4-CTL …

Natural killer (NK) cells contribute to a variety of innate immune responses to viruses, tumors
and allogeneic cells. However, our understanding of NK cell biology is severely limited by …

Human immunodeficiency virus (HIV) infection induces immunological dysfunction, which
limits the elimination of HIV-infected cells during treated infection. Identifying and targeting …

In response to infection, CD8+ T cells integrate multiple signals and undergo an exponential
increase in cell numbers. Simultaneously, a dynamic differentiation process occurs, resulting …

Both CD4+ T cell help and IL-2 have been postulated to “program” activated CD8+ T cells for
memory cell development. However, the linkage between these two signals has not been …

E-cadherin is best characterized as adherens junction protein, which through homotypic
interactions contributes to the maintenance of the epithelial barrier function. In epithelial …

The literature surrounding KLRG1 has primarily focused on NK and CD8+ T cells. However,
there is evidence that the most suppressive Tregs express KLRG1. Until now, the role of …

Killer cell lectin-like receptor G1 (KLRG1) is one of several inhibitory killer cell lectin-like
receptors expressed by NK cells and T lymphocytes, mainly CD8+ effector/memory cells that …