Clinical management of metastatic colorectal cancer in the era of precision medicine
F Ciardiello, D Ciardiello, G Martini… - CA: a cancer journal …, 2022 - Wiley Online Library
Colorectal cancer (CRC) represents approximately 10% of all cancers and is the second
most common cause of cancer deaths. Initial clinical presentation as metastatic CRC …
most common cause of cancer deaths. Initial clinical presentation as metastatic CRC …
[HTML][HTML] Dysregulated FOXM1 signaling in the regulation of cancer stem cells
Since the introduction of the cancer stem cell (CSC) paradigm, significant advances have
been made in understanding the functional and biological plasticity of these elusive …
been made in understanding the functional and biological plasticity of these elusive …
Integrated approaches for precision oncology in colorectal cancer: The more you know, the better
P Andrei, P Battuello, G Grasso, E Rovera… - Seminars in cancer …, 2022 - Elsevier
Colorectal cancer (CRC) is one of the most common human malignancies accounting for
approximately 10% of worldwide cancer incidence and mortality. While early-stage CRC is …
approximately 10% of worldwide cancer incidence and mortality. While early-stage CRC is …
[HTML][HTML] Advances in colon cancer research: in vitro and animal models
Modelling human colon cancer has long been the ambition of researchers and oncologists
with the aim to better replicate disease progression and treatment response. Advances in …
with the aim to better replicate disease progression and treatment response. Advances in …
Serrated colorectal cancer: Preclinical models and molecular pathways
A Aiderus, N Barker, V Tergaonkar - Trends in Cancer, 2024 - cell.com
Serrated lesions are histologically heterogeneous, and detection can be challenging as
these lesions have subtle features that may be missed by endoscopy. Furthermore, while …
these lesions have subtle features that may be missed by endoscopy. Furthermore, while …
Claudin-2 promotes colorectal cancer liver metastasis and is a biomarker of the replacement type growth pattern
Claudin-2 promotes breast cancer liver metastasis by enabling seeding and early cancer
cell survival. We now demonstrate that Claudin-2 is functionally required for colorectal …
cell survival. We now demonstrate that Claudin-2 is functionally required for colorectal …
Dysregulation of MiR-144-5p/RNF187 axis contributes to the progression of colorectal cancer
Z Gao, J Jiang, L Hou, B Zhang - Journal of translational internal …, 2022 - degruyter.com
Background and Objectives RING finger protein 187 (RNF187) belongs to RING domain-
containing E3 ligases family, which was recently reported to be involved in oncogenesis and …
containing E3 ligases family, which was recently reported to be involved in oncogenesis and …
[HTML][HTML] From crypts to cancer: a holistic perspective on colorectal carcinogenesis and therapeutic strategies
E Gharib, GA Robichaud - International journal of molecular sciences, 2024 - mdpi.com
Colorectal cancer (CRC) represents a significant global health burden, with high incidence
and mortality rates worldwide. Recent progress in research highlights the distinct clinical …
and mortality rates worldwide. Recent progress in research highlights the distinct clinical …
Identification of potential therapeutic targets associated with diagnosis and prognosis of colorectal cancer patients based on integrated bioinformatics analysis
Colorectal cancer (CRC) is the most common malignancy of digestive system with significant
mortality rate. CRC patients with comparable clinical symptoms or at similar stages of the …
mortality rate. CRC patients with comparable clinical symptoms or at similar stages of the …
Transcriptomes of the tumor-adjacent normal tissues are more informative than tumors in predicting recurrence in colorectal cancer patients
Background Previous investigations of transcriptomic signatures of cancer patient survival
and post-therapy relapse have focused on tumor tissue. In contrast, here we show that in …
and post-therapy relapse have focused on tumor tissue. In contrast, here we show that in …