The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …

Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …

Mitochondria have recently emerged as key drivers of inflammation associated with cell
death. Many of the pro-inflammatory pathways activated during cell death occur upon …

Regulated cell death (RCD) relies on activation and recruitment of pore-forming proteins
(PFPs) that function as executioners of specific cell death pathways: apoptosis regulator …

Eukaryotic cells can undergo different forms of programmed cell death, many of which
culminate in plasma membrane rupture as the defining terminal event,,,,,–. Plasma …

According to the endosymbiotic theory, most of the DNA of the original bacterial
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …

In multicellular organisms the regulated cell death apoptosis is critically important for both
ontogeny and homeostasis. Mitochondria are indispensable for stress-induced apoptosis …

Apoptosis is a regulated cellular pathway that ensures that a cell dies in a structured fashion
to prevent negative consequences for the tissue or the organism. Dysfunctional apoptosis is …

Traditionally, mitochondria are known as" the powerhouse of the cell," responsible for
energy (ATP) generation (by the electron transport chain, oxidative phosphorylation, the …

Mitochondria are cellular organelles with a major role in many cellular processes, including
not only energy production, metabolism, and calcium homeostasis but also regulated cell …