High‐throughput (HT) screening drug discovery, during which thousands or millions of
compounds are screened, remains the key methodology for identifying active chemical …

Cell-based assays for compound screening and profiling are fundamentally important in life
sciences, chemical biology and pharmaceutical research. Most cell assays measure the …

Acoustic droplet ejection (ADE)–open port interface (OPI)–mass spectrometry (MS) has
recently been introduced as a versatile analytical method that combines fast and contactless …

Potency assessment of monoclonal antibodies or corresponding biosimilars in cell-based
assays is an essential prerequisite in biopharmaceutical research and development …

In pharmaceutical research and development, cell‐based assays are primarily used with
readout that rely on fluorescence‐based and other label‐dependent techniques for analysis …

This chapter describes the development of high‐throughput (HT) and ultrahigh‐throughput
(uHT) MALDI‐TOF MS and applications to screening of assays and chemical reactions. The …

Fast computational evaluation and classification of concentration responses for hundreds of
metabolites represented by their mass-to-charge (m/z) ratios is indispensable for unraveling …

Acoustic droplet ejection-open port interface-mass spectrometry (ADE-OPI-MS) is a novel
label-free analytical technique, promising to become a versatile readout for high-throughput …

Recent advances in label-free high-throughput screening via matrix-assisted laser
desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) offer …

Matrix-assisted laser desorption/ionization (MALDI) is a soft ionization technique discovered
more than 30 years ago by Karas and Hillenkamp and by Tanaka et al.[1, 2]. MALDI …