Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …

Rhodopsin is a prototypical G protein-coupled receptor (GPCR) critical for vertebrate vision.
Research on GPCR signaling states has been facilitated using llama-derived nanobodies …

G protein-coupled receptors (GPCRs) are allosteric proteins, because their signal
transduction relies on interactions between topographically distinct, yet conformationally …

Rationale: Chronic obstructive pulmonary disease (COPD), in particular emphysema, is
characterized by loss of parenchymal alveolar tissue and impaired tissue repair. Wingless …

After synthesis, proteins are folded into their native conformations aided by molecular
chaperones. Dysfunction in folding caused by genetic mutations in numerous genes causes …

For more than 30 years, WNT/β-catenin and planar cell polarity signaling has formed the
basis for what we understand to be the primary output of the interaction between WNTs and …

Skeletal muscle (SkM) lipid composition plays an essential role in physiological muscle
maintenance and exercise performance. Thyroid hormones (THs) regulate muscle formation …