Mean platelet volume (MPV): new perspectives for an old marker in the course and prognosis of inflammatory conditions

A Korniluk, OM Koper-Lenkiewicz… - Mediators of …, 2019 - Wiley Online Library
Platelet size has been demonstrated to reflect platelet activity and seems to be a useful
predictive and prognostic biomarker of cardiovascular events. It is associated with a variety …

Thrombosis and platelets: an update

M Koupenova, BE Kehrel, HA Corkrey… - European heart …, 2017 - academic.oup.com
Haemostasis and thrombosis are complex, multifactorial processes. There is an evolving
understanding of the mechanisms influencing vascular occlusion and the role of …

[HTML][HTML] SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

S Zhang, Y Liu, X Wang, L Yang, H Li, Y Wang… - Journal of hematology & …, 2020 - Springer
Background Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic
state that places them at a dramatically increased lethal risk. Although platelet activation is …

[HTML][HTML] Platelets contribute to disease severity in COVID‐19

TJ Barrett, S Bilaloglu, M Cornwell, HM Burgess… - Journal of Thrombosis …, 2021 - Elsevier
Objective Heightened inflammation, dysregulated immunity, and thrombotic events are
characteristic of hospitalized COVID‐19 patients. Given that platelets are key regulators of …

[PDF][PDF] Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

MH Chen, LM Raffield, A Mousas, S Sakaue… - Cell, 2020 - cell.com
Most loci identified by GWASs have been found in populations of European ancestry (EUR).
In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including …

[HTML][HTML] COVID-19 induces a hyperactive phenotype in circulating platelets

SP Comer, S Cullivan, PB Szklanna, L Weiss… - PLoS …, 2021 - journals.plos.org
Coronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2), has affected over 30 million globally to date …

The incredible journey: From megakaryocyte development to platelet formation

KR Machlus, JE Italiano Jr - Journal of Cell Biology, 2013 - rupress.org
Circulating blood platelets are specialized cells that prevent bleeding and minimize blood
vessel injury. Large progenitor cells in the bone marrow called megakaryocytes (MKs) are …

The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review.

YU Budak, M Polat, K Huysal - Biochemia medica, 2016 - hrcak.srce.hr
Sažetak Platelet indices (PI)—plateletcrit, mean platelet volume (MPV) and platelet
distribution width (PDW)—are a group of derived platelet parameters obtained as a part of …

Mean platelet volume: a link between thrombosis and inflammation?

A Yuri Gasparyan, L Ayvazyan… - Current …, 2011 - ingentaconnect.com
Platelet activation is a link in the pathophysiology of diseases prone to thrombosis and
inflammation. Numerous platelet markers, including mean platelet volume (MPV), have been …

New roles for mean platelet volume measurement in the clinical practice?

P Noris, F Melazzini, CL Balduini - Platelets, 2016 - Taylor & Francis
Several hundreds of studies recently investigated mean platelet volume (MPV) as measured
by electronic cell counters in a wide variety of acquired diseases, and most of them found …