The plasticity of skeletal muscle can be traced down to extensive metabolic, structural and
molecular remodeling at the single fiber level. Skeletal muscle is comprised of different fiber …

Skeletal muscle injuries occur frequently in daily life and exercise. Understanding the
mechanisms of regeneration is critical for accelerating the repair and regeneration of …

Adult skeletal muscle stem cells, or satellite cells (SCs), regenerate functional muscle
following transplantation into injured or diseased tissue. To gain insight into human SC …

Fibroblast growth factors (FGFs) are essential for self‐renewal of skeletal muscle stem cells
(satellite cells) and required for maintenance and repair of skeletal muscle. Satellite cells …

Repair of damaged tissue requires the coordinated action of inflammatory and tissue-
specific cells to restore homeostasis, but the underlying regulatory mechanisms are poorly …

Monocyte/macrophage polarization in skeletal muscle regeneration is ill defined. We used
CD11b-diphtheria toxin receptor transgenic mice to transiently deplete monocytes …

Abstract p38 MAPKs play a central role in orchestrating the cellular response to stress and
inflammation and in the regulation of myogenesis. Potent inhibitors of p38 MAPKs have …

Adult stem cells (ASCs) are tissue resident stem cells responsible for tissue homeostasis
and regeneration following injury. In uninjured tissues, ASCs exist in a nonproliferating …

It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play
key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in …

The mitogen-activated protein kinases (MAPKs) are key regulators of cell growth and
survival in physiological and pathological processes. Aberrant MAPK signaling plays a …