[HTML][HTML] The role of Th17 and Treg cells in normal pregnancy and unexplained recurrent spontaneous abortion (URSA): New insights into immune mechanisms

C Tang, W Hu - Placenta, 2023 - Elsevier
Recurrent spontaneous abortion (RSA) has various causes, including chromosomal
abnormalities, a prethrombotic state, and abnormal uterine anatomical factors. However, in …

Placenta: an old organ with new functions

S Khorami-Sarvestani, N Vanaki, S Shojaeian… - Frontiers in …, 2024 - frontiersin.org
The transition from oviparity to viviparity and the establishment of feto-maternal
communications introduced the placenta as the major anatomical site to provide nutrients …

Mesenchymal stem cells enhance Treg immunosuppressive function at the fetal-maternal interface

D Zhang, Y Lin, Y Li, D Zhao, M Du - Journal of reproductive immunology, 2021 - Elsevier
Well-regulated maternal-fetal immune tolerance is a prerequisite for normal pregnancy.
Hyperactivated immune cells and overwhelming inflammatory responses trigger adverse …

Immunologic deviations in recurrent spontaneous abortion mouse model

H Ansariniya, F Zare, N Mosaffa, F Idali… - American Journal of …, 2022 - Wiley Online Library
Background Recurrent spontaneous abortion (RSA) or recurrent pregnancy loss (RPL) is an
abnormality that has a great impact on women's quality of life. RSA is defined as at least …

In-utero transfer of decidualized endometrial stromal cells increases the frequency of regulatory T cells and normalizes the abortion rate in the CBA/J × DBA/2 …

K Zarnani, K Zarnani, N Maslehat-Lay… - Frontiers in …, 2024 - frontiersin.org
Introduction Failure to adequate decidualization leads to adverse pregnancy outcomes
including pregnancy loss. Although there are plenty of reports underscoring immune …

Study the effect of recombinant leukemia inhibitory factor on maintenance of pregnancy and frequency of regulatory T cells in abortion-prone mice

H Ansariniya, H Hadinedoushan, F Zare, F Idali… - International …, 2023 - Elsevier
Recurrent spontaneous abortion (RSA) can have a significant impact on a woman's quality
of life. Understanding the mechanisms behind abortion is crucial for developing potential …

Regulatory T cell adoptive transfer alters uterine immune populations, increasing a novel MHC-IIlow macrophage associated with healthy pregnancy

EL Lewis, ER Reichenberger, L Anton… - Frontiers in …, 2023 - frontiersin.org
Intrauterine fetal demise (IUFD)–fetal loss after 20 weeks–affects 6 pregnancies per 1,000
live births in the United States, and the majority are of unknown etiology. Maternal systemic …

The Role of Regulatory T Cells and Their Therapeutic Potential in Hypertensive Disease of Pregnancy: A Literature Review

K Headen, V Jakaite, VA Mesaric, C Scotta… - International Journal of …, 2024 - mdpi.com
Hypertensive disorders of pregnancy (HDP), including preeclampsia (PE) and gestational
hypertension (GH), are major causes of maternal and foetal morbidity and mortality. This …

Vitamin D affects antiphospholipid syndrome by regulating T cells

R Huo, Y Yang, C Wei, X Huo… - International …, 2024 - spandidos-publications.com
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by arterial
and/or venous thrombosis, pathological pregnancies and persistent antiphospholipid …

Impact of regulatory T cell therapy on immune cell composition and fetal survival rate in abortion prone mice

F Idali, H Golshahi, L Katouzian… - Reproduction …, 2023 - CSIRO Publishing
Context Implantation of fertilised eggs and survival of a semi-allogenic embryo rely on the
interactions between the cells and molecules preparing the uterus. We investigated the …