BACKGROUND Chromatin is the essential medium through which transcription factors,
signaling pathways, and other cues alter gene activity and cellular phenotypes. It assumes …

The importance of tree genetic variability in the ability of forests to respond and adapt to
environmental changes is crucial in forest management and conservation. Along with …

Bivalent chromatin is characterized by the simultaneous presence of H3K4me3 and
H3K27me3, histone modifications generally associated with transcriptionally active and …

Human blastocysts are comprised of the first three cell lineages of the embryo:
trophectoderm, epiblast and primitive endoderm, all of which are essential for early …

Plant genomes encode a complex and evolutionary diverse regulatory grammar that forms
the basis for most life on earth. A wealth of regulome and epigenome data have been …

Epigenetic reprogramming in the germline contributes to the erasure of epigenetic
inheritance across generations in mammals but remains poorly characterized in plants. Here …

Deciphering mechanisms in cell-fate decisions requires single-cell holistic reconstructions of
multidimensional epigenomic states in transcriptional regulation. Here we develop CoTECH …

Endogenous retroviruses (ERVs) have been proposed as a driving force for the evolution of
the mammalian placenta, however, the contribution of ERVs to placental development and …

Alterations in the epigenome and metabolism affect molecular rewiring of cancer cells
facilitating cancer development and progression. Modulation of histone and DNA …

Background Individuals affected with autism often suffer additional co-morbidities such as
intellectual disability. The genes contributing to autism cluster on a relatively limited number …