Endothelial cells and mesenchymal cells are two different cell types with distinct
morphologies, phenotypes, functions, and gene profiles. Accumulating evidence, notably …

Cilia are membrane-bounded, centriole-derived projections from the cell surface that contain
a microtubule cytoskeleton, the ciliary axoneme, surrounded by a ciliary membrane …

A wide range of cell types depend on mechanically induced signals to enable appropriate
physiological responses. The skeleton is particularly dependent on mechanical information …

Primary cilia are sensory organelles that translate extracellular chemical and mechanical
cues into cellular responses. Bone is an exquisitely mechanosensitive organ, and its …

It has long been thought that the effectiveness and efficiency of physical therapy would
improve if our understanding of the cell biology/biochemistry that participates in mechanics …

▪ Abstract It has been a decade since a novel form of microtubule (MT)-based motility, ie,
intraflagellar transport (IFT), was discovered in Chlamydomonas flagella. Subsequent …

Although first described as early as 1898 and long considered a vestigial organelle of little
functional importance, the primary cilium has become one of the hottest research topics in …

Although cardiac abnormalities have been observed in a growing class of human disorders
caused by defective primary cilia, the function of cilia in the heart remains an underexplored …

Cilia are microtubule-based structures that protrude from the cell surface and function as
sensors for mechanical and chemical environmental cues that regulate cellular …

Cysts in the kidney are among the most common inherited human pathologies, and recent
research has uncovered that a defect in cilia-mediated signaling activity is a key factor that …