Bone morphogenetic protein-2 (BMP-2) is currently the only Food and Drug Administration
(FDA)-approved osteoinductive growth factor used as a bone graft substitute. However, with …

Background context Increasingly, reports of frequent and occasionally catastrophic
complications associated with use of recombinant human bone morphogenetic protein-2 …

Bone morphogenetic proteins (BMPs) are responsible for bone formation during
embryogenesis and bone regeneration and remodeling. The osteoinductive action of BMPs …

Background: Recombinant human bone morphogenetic protein-2 (rhBMP-2) is used as a
bone graft substitute in spinal fusion, which unites (fuses) bones in the spine. The accuracy …

Background: Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used
to promote fusion in spinal surgery, but its safety has been questioned. Purpose: To evaluate …

The combination of recombinant human bone morphogenetic protein-2 (rhBMP-2) on an
absorbable collagen sponge (ACS) carrier has been shown to induce bone formation in a …

Study Design. A retrospective review of patients who underwent an anterior cervical fusion
using recombinant human bone morphogenetic protein (rhBMP)-2 with an absorbable …

Over the past several decades, recombinant human bone morphogenetic proteins (rhBMPs)
have been the most extensively studied and widely used osteoinductive agents for clinical …

There is a growing socio-economic need for effective strategies to repair damaged bone
resulting from disease, trauma and surgical intervention. Bone tissue engineering has …

Increasingly, adverse events (AE) attributed to utilizing BMP/INFUSE (Bone Morphogenetic
Protein, Medtronic, Memphis, TN, USA)“off-label” in spine surgery are being reported. In …