Phase I and II drug metabolizing enzymes (DME) and drug transporters are involved in the
absorption, distribution, metabolism as well as elimination of many therapeutic agents …

Abstract Background Antiepileptic drugs (AEDs) are effective medications available for
epilepsy. However, many patients do not respond to this treatment and become resistant …

Objective To determine whether common polymorphisms in CACNA1G, CACNA1H,
CACNA1I, and ABCB1 are associated with differential short‐term seizure outcome in …

Carbamazepine (CBZ), a dibenzazepine, is a tricyclic compound used in the treatment of
epilepsy, trigeminal neuralgia, and psychiatric mood disorders [1]. Serious adverse events …

Background. Epilepsy is one of the most common neurological disorders with about 30%
treatment failure rate. An interindividual variations in efficacy of antiepileptic drugs (AEDs) …

Aims: Several studies demonstrated a link between ABCB1 gene variants and the response
to treatment in epilepsy, but the results have been inconclusive. Here, we performed the first …

Epilepsy treatment is challenging due to heterogeneous syndromes, different seizure types
and higher inter-individual variability. Identification of genetic variants predicting drug …

Genetic polymorphisms are related to the concentration and efficacy of oxcarbazepine
(OXC). 10-Hydroxycarbazepine (MHD) is the major pharmacologically active metabolite of …

The cause of Parkinson's disease (PD) remains elusive, but environmental chemical
exposures have been postulated to be involved in the etiology of PD. We examined the …

ABCB1 Gene C3435T Polymorphism and Drug Resistance in Epilepsy: Evidence Based on
8604 Subjects - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …