In 1980, Furchgott and Zawadzki showed that the endothelial lining of blood vessels was
essential for the vasorelaxant effect of acetylcholine and showed that this effect was …

The possibility that transmission at some non‐adrenergic, non‐cholinergic (NANC) neuro‐
effector junctions is mediated by nitric oxide (NO) arose from the discoveries that NO …

Nitric oxide was identified as a biological intercellular messenger just over 20 years ago,
and its presence and potential importance in the nervous system was immediately noted …

Proteinase-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is cleaved and
activated by trypsin-like enzymes. PAR-2 is highly expressed by small intestinal enterocytes …

The distribution of nitric oxide synthase (NOS) immunoreactivity was investigated in the
guinea-pig small intestine. There were many immunoreactive nerve cell bodies in the …

Nitric oxide has a tantalizing role in health and disease: while many of its wide-ranging
effects are well known, there remains much more to explore and to learn about the …

Involvement of vasoactive intestinal peptide (VIP) and nitric oxide (NO) in neurally induced
relaxation was examined in smooth muscle from rat colon. Relaxation induced by field …

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists
were sceptical about its validity, largely because ATP was so well established as an …

Background: Nitric oxide (NO) may be an inhibitory neurotransmitter in the intestinal muscle.
The present study examined its role in human and canine jejunum. Methods: Mechanical …

The pattern of distribution and colocalization of nitric oxide-synthase (NOS) and NADPH-
diaphorase in the myenteric plexus of wholemount preparations of the antrum, duodenum …