BACKGROUND Liquid biopsies that are based on analysis of cell-free DNA from plasma
offer diagnostic information that is otherwise accessible conventionally through invasive …

The fetal fraction (FF) is a function of both biological factors and bioinformatics algorithms
used to interpret DNA sequencing results. It is an essential quality control component of …

Cell-free placental DNA (cfpDNA) is present in maternal circulation during gestation.
CfpDNA carries great potential as a research and clinical tool as it provides a means to …

Objective The present study aimed to evaluate and analyze the results of karyotyping by
amniocentesis and next generation sequencing (NGS)-based noninvasive prenatal DNA …

As an emerging biomarker, cell-free DNA (cfDNA) carries crucial genetic information for the
diagnosis of hereditary disease and cancer. However, test accuracy was severely …

Early cancer detection and localization using cell-free DNA (cfDNA) faces multiple
challenges, including the low fraction of tumor DNA in cfDNA and the molecular …

There is an increasing demand for prenatal paternity testing in the forensic applications,
which identify biological fathers before the birth of children. Currently, one of the most …

Background: To evaluate the clinical performance and clinical implementation of
noninvasive prenatal testing (NIPT) using fetal fraction (FF) enrichment. Methods: Both …

In 1997, the detection of male DNA in peripheral blood samples from women bearing male
fetuses proved that fetal DNA circulates in maternal plasma and serum [1]. Circulating “fetal” …

2022-05-13 Assigned to THE CHINESE UNIVERSITY OF HONG KONG reassignment THE
CHINESE UNIVERSITY OF HONG KONG ASSIGNMENT OF ASSIGNORS INTEREST (SEE …