Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives

A Kumari, RK Singh - Bioorganic chemistry, 2019 - Elsevier
Indole is a versatile pharmacophore, a privileged scaffold and an outstanding heterocyclic
compound with wide ranges of pharmacological activities due to different mechanisms of …

Current Development of Thiazole-Containing Compounds as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus

H Liu, T Xu, Z Xue, M Huang, T Wang… - ACS Infectious …, 2024 - ACS Publications
The emergence of multi-drug-resistant bacteria is threatening to human health and life
around the world. In particular, methicillin-resistant Staphylococcus aureus (MRSA) causes …

Indole-based derivatives as potential antibacterial activity against methicillin-resistance Staphylococcus aureus (MRSA)

HL Qin, J Liu, WY Fang, L Ravindar… - European journal of …, 2020 - Elsevier
Antibacterial-resistance speaks to an overall alarm, particularly in regards to the flare-up of
methicillin-resistance Staphylococcus aureus (MRSA), a classic reason for genuine skin and …

Thiazole-based analogs as potential antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) and their SAR elucidation

J Guo, Z Xie, W Ruan, Q Tang, D Qiao, W Zhu - European Journal of …, 2023 - Elsevier
In recent years, the overuse of antibiotics has resulted in the emergence of antibiotic
resistance, which is a serious global health problem. Methicillin-resistant Staphylococcus …

Structure-activity relationship studies of thiazole agents with potential anti methicillin-resistance Staphylococcus aureus (MRSA) activity

J Wang, S Long, Z Liu, KP Rakesh, R Verma… - Process …, 2023 - Elsevier
Due to the increasing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to
conventional antibiotics, further efforts are needed to develop new antimicrobial agents …

Development of isatin-thiazolo [3, 2-a] benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and …

WM Eldehna, MA El Hassab, MF Abo-Ashour… - Bioorganic …, 2021 - Elsevier
In the current medical era, human health is experiencing numerous challenges, particularly
the human malignancies. Therefore, the therapeutic arsenal for these malignancies is to be …

A mini review on isatin, an anticancer scaffold with potential activities against neglected tropical diseases (NTDs)

S Chowdhary, Shalini, A Arora, V Kumar - Pharmaceuticals, 2022 - mdpi.com
Isatin, chemically an indole-1 H-2, 3-dione, is recognised as one of the most attractive
therapeutic fragments in drug design and development. The template has turned out to be …

Synthesis, characterization and biological activities of new Schiff base compound and its lanthanide complexes

AA Abu-Yamin, MS Abduh, SAM Saghir, N Al-Gabri - Pharmaceuticals, 2022 - mdpi.com
The thermal condensation of 3-(2-Furyl) acrolein with 2-Amino-6-ethoxybenzothiazole
generated a new Schiff base,(1E, 2E)-N-(6-ethoxybenzo [d] thiazol-2-yl)-3-(furan-2-yl) prop …

Recent advances in isatin hybrids as potential anticancer agents

Z Ding, M Zhou, C Zeng - Archiv der Pharmazie, 2020 - Wiley Online Library
The isatin framework is a useful template for the development of novel anticancer agents.
This is exemplified by the fact that several isatin‐based anticancer agents, such as …

Antitubercular properties of thiazolidin-4-ones–A review

N Trotsko - European Journal of Medicinal Chemistry, 2021 - Elsevier
Thiazolidin-4-one scaffold has great potential for medicinal chemistry and is of interest to
scientists in view of wide spectrum of biological activity. This scaffold is often used for …