Ca 2+ is a highly versatile intracellular signal that operates over a wide temporal range to
regulate many different cellular processes. An extensive Ca 2+-signalling toolkit is used to …

В работе представлен анализ литературы, синтез результатов экспериментальных и
клинических исследований, а также современное представление о механизмах …

The intracellular regulator of G protein signalling (RGS) proteins were first identified as
GTPase activating proteins (GAPs) for heterotrimeric G proteins, however, it was later found …

Alteration in [Ca2+] i (the intracellular concentration of Ca2+) is a key regulator of many
cellular processes. To allow precise regulation of [Ca2+] i and a diversity of signalling by this …

Mutations in genes encoding components of the heterotrimeric G-protein complex were
previously shown to confer altered sensitivity to increased levels of d-glucose. This suggests …

Signaling pathways that rely on the controlled release and/or accumulation of calcium ions
are important in a variety of developmental events in the vertebrate embryo, affecting cell …

Regulators of G-protein signalling (RGS) proteins are a large and diverse family initially
identified as GTPase activating proteins (GAPs) of heterotrimeric G-protein Gα-subunits. At …

Fragile X syndrome, a common form of inherited mental retardation, is caused by the
absence of the fragile X mental retardation protein (FMRP) due to a mutation in the FMR1 …

An increasing number of putative therapeutic targets have been identified in recent years for
the treatment of neuronal pathophysiologies including pain, epilepsy, stroke and …

Increased osteoclastic resorption leads to many bone diseases, including osteoporosis and
rheumatoid arthritis. While rapid progress has been made in characterizing osteoclast …