Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The
canonical model of RTK endocytosis involves rapid internalization of an RTK activated by …

In yeast and mammalian cells, endosomal sorting complexes required for transport (ESCRT)
assist in sorting ubiquitinated proteins into intralumenal vesicles (ILVs) of multivesicular …

The intraluminal vesicles (ILVs) of endosomes mediate the delivery of activated signaling
receptors and other proteins to lysosomes for degradation, but they also modulate …

This review article describes the pathways and mechanisms of endocytosis and post-
endocytic sorting of the EGF receptor (EGFR/ErbB1) and other members of the ErbB family …

The ESCRT complexes and associated proteins comprise a major pathway for the
lysosomal degradation of transmembrane proteins and are critical for receptor …

Cbl proteins are ubiquitin ligases and multifunctional adaptor proteins that are implicated in
the regulation of signal transduction in various cell types and in response to different stimuli …

Ubiquitin modification of many cellular proteins targets them for proteasomal degradation,
but in addition can also serve non-proteolytic functions. Over the last years, a significant …

Evidence indicates that Alix, an accessory protein of the endosomal sorting complex
required for transport (ESCRT), is involved in the biogenesis of extracellular vesicles (EVs) …

ALIX/AIP1 functions in enveloped virus budding, endosomal protein sorting, and many other
cellular processes. Retroviruses, including HIV-1, SIV, and EIAV, bind and recruit ALIX …

The human immunodeficiency virus (HIV) type-1 viral protein U (Vpu) protein enhances the
release of diverse retroviruses from human, but not monkey, cells and is thought to do so by …