Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …

For over 15 years, the peripheral benzodiazepine receptor (PBR), recently named
translocator protein 18 kDa (TSPO) has been studied as a biomarker of reactive gliosis and …

The transfer of cholesterol from the outer to the inner mitochondrial membrane is the rate-
limiting step in hormone-induced steroid formation. To ensure that this step is achieved …

Background Rat oligonucleotide microarrays were used to detect changes in gene
expression in the dorsal root ganglion (DRG) 3 days following sciatic nerve transection …

Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are
implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids …

In health, microglia reside as quiescent guardian cells ubiquitously, but isolated without any
cell‐cell contacts amongst themselves, throughout the normal CNS. In disease, however …

Cholesterol transport from the outer to the inner mitochondrial membrane is the rate-
determining step in steroid and bile acid biosyntheses. Biochemical, pharmacological and …

Neurosteroids are synthetized in the central and the peripheral nervous system, in glial cells,
and also in neurons, from cholesterol or sieroidal precursors imported from peripheral …

Due to its channel-like properties, the peripheral-type benzodiazepine receptor (PBR) has
been renamed the translocator protein (TSPO). In eukaryotes, the TSPO is primarily located …

Neuroactive steroids include synthetic steroidal compounds and endogenous steroids,
produced by endocrine glands (hormonal steroids) or the nervous tissue (neurosteroids) …