Recent developments in asymmetric multicomponent reactions

C de Graaff, E Ruijter, RVA Orru - Chemical Society Reviews, 2012 - pubs.rsc.org
Multicomponent reactions (MCRs) receive increasing attention because they address both
diversity and complexity in organic synthesis. Thus, in principle diverse sets of relatively …

Stereocontrolled domino reactions

H Pellissier - Chemical Reviews, 2013 - ACS Publications
A domino reaction has been defined by Tietze as a reaction involving two or more bond-
forming transformations that take place under the same reaction conditions, without adding …

Malleable and self-healing covalent polymer networks through tunable dynamic boronic ester bonds

OR Cromwell, J Chung, Z Guan - Journal of the American …, 2015 - ACS Publications
Despite numerous strategies involving dynamic covalent bond exchange for dynamic and
self-healing materials, it remains a challenge to be able to tune the malleability and self …

Boronic acids and esters in the Petasis-borono Mannich multicomponent reaction

NR Candeias, F Montalbano, PMSD Cal… - Chemical …, 2010 - ACS Publications
Organoboron reagents have been widely explored in organic synthesis as a suitable tool for
the formation of new CC bonds. Such compounds are captivating not only because of their …

Development of chiral thiourea catalysts and its application to asymmetric catalytic reactions

Y Takemoto - Chemical and Pharmaceutical Bulletin, 2010 - jstage.jst.go.jp
We have developed several multifunctional thiourea catalysts bearing a tertiary amine or an
1, 2-amino alcohol in expectation of their synchronous activation of a nucleophile and an …

Catalytic enantioselective Petasis-type reaction of quinolines catalyzed by a newly designed thiourea catalyst

Y Yamaoka, H Miyabe, Y Takemoto - Journal of the American …, 2007 - ACS Publications
A newly designed thiourea catalyst provides sufficient activation of organoboronic acids to
facilitate the enantioselective Petasis transformation of quinolines even at low temperatures …

Discovery and application of asymmetric reaction by multi-functional thioureas

H Miyabe, Y Takemoto - Bulletin of the Chemical Society of …, 2008 - academic.oup.com
Novel bifunctional organocatalysts, which possess a thiourea moiety and an amino group,
were designed and synthesized. We discovered that bifunctional thiourea bearing a tertiary …

[PDF][PDF] Lithiated carbamates: chiral carbenoids for iterative homologation of boranes and boronic esters

JL Stymiest, G Dutheuil, A Mahmood… - … EDITION IN ENGLISH-, 2007 - academia.edu
All air and water sensitive reactions were carried out in oven dried glassware under a
nitrogen atmosphere. Solvents were dried by standard methods. 1 NMR spectra were …

Amphoteric α-boryl aldehydes

Z He, AK Yudin - Journal of the American Chemical Society, 2011 - ACS Publications
A new class of stable molecules, α-boryl aldehydes, has been prepared from oxiranyl N-
methyliminodiacetyl boronates by a 1, 2-boryl migration with concomitant epoxide scission …

Asymmetric Petasis reactions catalyzed by chiral biphenols

S Lou, SE Schaus - Journal of the American Chemical Society, 2008 - ACS Publications
Chiral biphenols catalyze the enantioselective Petasis reaction of alkenyl boronates,
secondary amines, and ethyl glyoxylate. The reaction requires the use of 15 mol% of (S) …