Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …

Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

The function of deciphering the biological information encoded by the glycome, which is the
entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in …

This review is intended for general readers who would like a basic foundation in
carbohydrate structure and function, lectin biology, and the implications of glycobiology in …

Abstract Galectin-9 (Gal-9) is a β-galactoside binding lectin known for its immunomodulatory
role in various microbial infections. Gal-9 is expressed in all organ systems and localized in …

Glycosylation produces a diverse and abundant repertoire of glycans, which are collectively
known as the glycome. Glycans are one of the four fundamental macromolecular …

The importance of protein glycosylation in the migration of immune cells throughout the body
has been extensively appreciated. However, our awareness of the impact of glycosylation …

Galectins, which were first characterized in the mid-1970s, were assigned a role in the
recognition of endogenous ('self') carbohydrate ligands in embryogenesis, development and …

Regulatory signals provide negative input to immunological networks promoting resolution
of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily …

Galectins are a family of mammalian carbohydrate-binding proteins expressed by many cell
types. Galectins can function intracellularly and can also be secreted to bind to cell surface …