Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
Recent progress in phospholipase A2 research: from cells to animals to humans
M Murakami, Y Taketomi, Y Miki, H Sato… - Progress in lipid …, 2011 - Elsevier
Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …
related enzymes, which are subdivided into several classes including low-molecular-weight …
The phospholipase A2 superfamily and its group numbering system
RH Schaloske, EA Dennis - … et Biophysica Acta (BBA)-Molecular and Cell …, 2006 - Elsevier
The superfamily of phospholipase A2 (PLA2) enzymes currently consists of 15 Groups and
many subgroups and includes five distinct types of enzymes, namely the secreted PLA2s …
many subgroups and includes five distinct types of enzymes, namely the secreted PLA2s …
Biochemistry and Physiology of Mammalian Secreted Phospholipases A2
Phospholipases A2 (PLA2s) are esterases that hydrolyze the sn-2 ester of
glycerophospholipids and constitute one of the largest families of lipid hydrolyzing enzymes …
glycerophospholipids and constitute one of the largest families of lipid hydrolyzing enzymes …
Control of free arachidonic acid levels by phospholipases A2 and lysophospholipid acyltransferases
Arachidonic acid (AA) and its oxygenated derivatives, collectively known as the eicosanoids,
are key mediators of a wide variety of physiological and pathophysiological states. AA …
are key mediators of a wide variety of physiological and pathophysiological states. AA …
Phospholipase A2 regulation of lipid droplet formation
The classical regard of lipid droplets as mere static energy-storage organelles has evolved
dramatically. Nowadays these organelles are known to participate in key processes of cell …
dramatically. Nowadays these organelles are known to participate in key processes of cell …
Group V secreted phospholipase A2 is upregulated by IL-4 in human macrophages and mediates phagocytosis via hydrolysis of ethanolamine phospholipids
Studies on the heterogeneity and plasticity of macrophage populations led to the
identification of two major polarization states: classically activated macrophages or M1 …
identification of two major polarization states: classically activated macrophages or M1 …
Oxidative stress and arachidonic acid mobilization
MA Balboa, J Balsinde - Biochimica et Biophysica Acta (BBA)-Molecular …, 2006 - Elsevier
Reactive oxygen species are known to contribute to tissue damage during injury and
inflammation. However, these species can also be sensed by the cells and trigger …
inflammation. However, these species can also be sensed by the cells and trigger …
Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice
M Murakami, Y Taketomi, C Girard, K Yamamoto… - Biochimie, 2010 - Elsevier
Among the emerging phospholipase A2 (PLA2) superfamily, the secreted PLA2 (sPLA2)
family consists of low-molecular-mass, Ca2+-requiring extracellular enzymes with a His-Asp …
family consists of low-molecular-mass, Ca2+-requiring extracellular enzymes with a His-Asp …
Omega-3 versus Omega-6 fatty acid availability is controlled by hydrophobic site geometries of phospholipase A2s
D Hayashi, VD Mouchlis, EA Dennis - Journal of Lipid Research, 2021 - ASBMB
Human phospholipase A 2 s (PLA 2) constitute a superfamily of enzymes that hydrolyze the
sn-2 acyl-chain of glycerophospholipids, producing lysophospholipids and free fatty acids …
sn-2 acyl-chain of glycerophospholipids, producing lysophospholipids and free fatty acids …