ROS: basic concepts, sources, cellular signaling, and its implications in aging pathways

AJPO de Almeida, JCPL de Oliveira… - Oxidative medicine …, 2022 - Wiley Online Library
Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …

[HTML][HTML] Complex interplay between autophagy and oxidative stress in the development of pulmonary disease

W Ornatowski, Q Lu, M Yegambaram, AE Garcia… - Redox biology, 2020 - Elsevier
The autophagic pathway involves the encapsulation of substrates in double-membraned
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …

Itaconate: the poster child of metabolic reprogramming in macrophage function

LAJ O'Neill, MN Artyomov - Nature Reviews Immunology, 2019 - nature.com
Itaconate is one of the best examples of the consequences of metabolic reprogramming
during immunity. It is made by diverting aconitate away from the tricarboxylic acid cycle …

Roles of autophagy in oxidative stress

HR Yun, YH Jo, J Kim, Y Shin, SS Kim… - International journal of …, 2020 - mdpi.com
Autophagy is a catabolic process for unnecessary or dysfunctional cytoplasmic contents by
lysosomal degradation pathways. Autophagy is implicated in various biological processes …

[HTML][HTML] Oxidative stress: a concept in redox biology and medicine

H Sies - Redox biology, 2015 - Elsevier
Abstract “Oxidative stress” as a concept in redox biology and medicine has been formulated
in 1985; at the beginning of 2015, approx. 138,000 PubMed entries show for this term. This …

Oxidative stress and autophagy: the clash between damage and metabolic needs

G Filomeni, D De Zio, F Cecconi - Cell Death & Differentiation, 2015 - nature.com
Autophagy is a catabolic process aimed at recycling cellular components and damaged
organelles in response to diverse conditions of stress, such as nutrient deprivation, viral …

Glutathione: new roles in redox signaling for an old antioxidant

K Aquilano, S Baldelli, MR Ciriolo - Frontiers in pharmacology, 2014 - frontiersin.org
The physiological roles played by the tripeptide glutathione have greatly advanced over the
past decades superimposing the research on free radicals, oxidative stress and, more …

The redox code

DP Jones, H Sies - Antioxidants & redox signaling, 2015 - liebertpub.com
Significance: The redox code is a set of principles that defines the positioning of the
nicotinamide adenine dinucleotide (NAD, NADP) and thiol/disulfide and other redox systems …

[HTML][HTML] Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria

H Zhong, H Yin - Redox biology, 2015 - Elsevier
Oxidative stress-induced lipid peroxidation has been associated with human physiology and
diseases including cancer. Overwhelming data suggest that reactive lipid mediators …

Oxidative stress

H Sies, C Berndt, DP Jones - Annual review of biochemistry, 2017 - annualreviews.org
Oxidative stress is two sided: Whereas excessive oxidant challenge causes damage to
biomolecules, maintenance of a physiological level of oxidant challenge, termed oxidative …