We are entering a new era in genomics where entire centromeric regions are accurately
represented in human reference assemblies. Access to these high-resolution maps will …

Since its initial release in 2000, the human reference genome has covered only the
euchromatic fraction of the genome, leaving important heterochromatic regions unfinished …

Repetitive DNA is a major organizational component of eukaryotic genomes, being
intrinsically related with their architecture and evolution. Tandemly repeated satellite DNAs …

Over 100 years of studies in Drosophila melanogaster and related species in the genus
Drosophila have facilitated key discoveries in genetics, genomics, and evolution. While high …

Abstract Satellite DNAs (SatDNA) are ubiquitously present in eukaryotic genomes and have
been recently associated with several biological roles. Understanding the evolution and …

Y chromosomes across diverse species convergently evolve a gene-poor, heterochromatic
organization enriched for duplicated genes, LTR retrotransposons, and satellite DNA …

Since their discovery more than 60 years ago, satellite repeats are still one of the most
enigmatic parts of eukaryotic genomes. Being non-coding DNA, satellites were earlier …

The karyotype, or number and arrangement of chromosomes, has varying levels of stability
across both evolution and disease. Karyotype changes often originate from DNA breaks …

A substantial fraction of the human genome is difficult to interrogate with short-read DNA
sequencing technologies due to paralogy, complex haplotype structures, or tandem repeats …

Abundant tandemly repeated satellite DNA is present in most eukaryotic genomes. Previous
limitations including a pervasive view that it was uninteresting junk DNA, combined with …